Evidence map›Paper›PMID 27752068›Full record

ReviewNature reviews. Neuroscience2016

Lasting impact of general anaesthesia on the brain: mechanisms and relevance.

Laszlo Vutskits, Zhongcong Xie

4 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 260 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
260citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03442179 unknown statusnot on this mapstarted 2019, after this paper: background citation

Cognitive Outcomes and Neuroimages Associated With Anesthesia-Related EEG Signatures

TypeobservationalSponsorMassachusetts General HospitalRan2019 to 2024Enrolled24ConditionsElderly, General Anesthesia
NCT04219033 unknown statusnot on this mapstarted 2020, after this paper: background citation

Correlation Between Postoperative Cognitive Function and EEG Parameters in Elderly Patients Undergoing Non-cardiac Major Surgery : Multi-center, Prospective, Observational Study

TypeobservationalSponsorAir Force Military Medical University, ChinaRan2020 to 2023Enrolled1,250ConditionsAging, Postoperative Cognitive Dysfunction, EEG With Periodic AbnormalitiesArmsEEG(Electroencephalogram) change
NCT05936853 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

The EPigenetic Consequences in Children of Intravenous vs Volatile Anaesthesia for Surgery (EPIVA) - A Randomised, Feasibility Trial

TypeinterventionalSponsorUniversity Hospital Southampton NHS Foundation TrustRan2023 to 2026Enrolled16ConditionsHypospadias, Anesthesia, Adverse Effect, Perioperative ComplicationArmsIntravenous approach to anaesthetic maintenance, Inhalational approach to anaesthetic maintenance
NCT06002568 naunknown statusnot on this mapstarted 2023, after this paper: background citation

) The Effect of Intraoperative Binaural Beats on the Quantity of Inhaled Anesthetic Gas Required for the Maintenance of General Anesthesia: a Randomized, Placebo Controlled Trial

TypeinterventionalSponsorSeoul National University HospitalRan2023 to 2025Enrolled122ConditionsAnesthesia, GeneralArmsSilent, Binaural beats
3 · Its place in the literature

Who cites it

260 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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200 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Laszlo VutskitsDepartment of Anesthesiology, Pharmacology and Intensive Care, University Hospitals of Geneva, 4 rue Gabrielle-Perret-Gentil, 1205 Geneva 4, Switzerland.
Zhongcong XieDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4310, Charlestown, Massachusetts 02129, USA.

Funding

Pathogenesis of Postoperative Cognitive DysfunctionR01AG041274 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Zhongcong Xie, Guang Yang · 2012 to 2026
$6.7M
General Anesthesia and Alzheimer's Disease NeuropathogenesisR01GM088801 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI XIE, ZHONGCONG · 2009 to 2017
$3.1M
Tau/P-Tau as Biomarkers of Anesthesia- and Surgery-Induced Cognitive Impairment in a Murine ModelR01HD086977 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI XIE, ZHONGCONG · 2016 to 2020
$1.8M
NICHD NIH HHS R01 HD086977NIGMS NIH HHS R01 GM088801
6 · The paper itself

Abstract

General anaesthesia is usually considered to safely induce a reversible brain state allowing the performance of surgery under optimal conditions. An increasing number of clinical and experimental observations, however, suggest that anaesthetic drugs, especially when they are administered at the extremes of age, can trigger long-term morphological and functional alterations in the brain. Here, we review available mechanistic data linking general-anaesthesia exposure to impaired cognitive performance in both young and mature nervous systems. We also provide a critical appraisal of the translational value of animal models and highlight the important challenges that need to be addressed to strengthen the link between laboratory work and clinical investigations in the field of anaesthesia-neurotoxicity research.

Indexed as

Age FactorsAnesthesia, GeneralAnestheticsAnimalsBrainCell DeathCognition DisordersHumansPostoperative ComplicationsTime FactorsAnesthetics

Identifiers

PMID27752068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.