ArticleScientific reports2016
Unsupervised data-driven stratification of mentalizing heterogeneity in autism.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition.Molecular psychiatry · 2018Pooled it
- Intact but Protracted Facial and Prosodic Emotion Recognition Among Autistic Adults.Journal of autism and developmental disorders · 2026Article
- From heterogeneity to translation: data‑driven subtyping of autism in a multilevel framework.Translational psychiatry · 2026Review
- Empathic Disequilibrium in Autistic Traits and CU Traits: Investigating Empathy Imbalance in Children.Research on child and adolescent psychopathology · 2026Article
- Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2025Article
- A cross-cultural examination of bi-directional mentalising in autistic and non-autistic adults.Molecular autism · 2025Article
- Understanding social behaviours across neurodiverse young people: roles of social cognition and self-regulation.BJPsych open · 2025Article
- Improving mentalizing deficits in older age with region-specific transcranial direct current stimulation.GeroScience · 2024Article
- Autism screening: an unsupervised machine learning approach.Health information science and systems · 2022Article
- Facial expression recognition is linked to clinical and neurofunctional differences in autism.Molecular autism · 2022Article
- Reexamining empathy in autism: Empathic disequilibrium as a novel predictor of autism diagnosis and autistic traits.Autism research : official journal of the International Society for Autism Research · 2022Article
- Understanding the nature of face processing in early autism: A prospective study.Journal of psychopathology and clinical science · 2022Article
- Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis.Molecular autism · 2022Article
- The Value of Patient Registries to Advance Basic and Translational Research in the Area of Traumatic Brain Injury.Frontiers in behavioral neuroscience · 2022Review
- Do animated triangles reveal a marked difficulty among autistic people with reading minds?Autism : the international journal of research and practice · 2021Review
- Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry.Communications biology · 2021Article
- Just a phase? Mapping the transition of behavioural problems from childhood to adolescence.Social psychiatry and psychiatric epidemiology · 2021Article
- "Reading the Mind in the Eyes" in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study.Autism research : official journal of the International Society for Autism Research · 2021Article
- Fractionating autism based on neuroanatomical normative modeling.Translational psychiatry · 2020Article
- Examining criterion-oriented validity of the Repetitive Behavior Scales for Early Childhood (RBS-EC) and the Video-Referenced Rating of Reciprocal Social Behavior (vrRSB).Development and psychopathology · 2020Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Individuals affected by autism spectrum conditions (ASC) are considerably heterogeneous. Novel approaches are needed to parse this heterogeneity to enhance precision in clinical and translational research. Applying a clustering approach taken from genomics and systems biology on two large independent cognitive datasets of adults with and without ASC (n = 694; n = 249), we find replicable evidence for 5 discrete ASC subgroups that are highly differentiated in item-level performance on an explicit mentalizing task tapping ability to read complex emotion and mental states from the eye region of the face (Reading the Mind in the Eyes Test; RMET). Three subgroups comprising 45-62% of ASC adults show evidence for large impairments (Cohen's d = -1.03 to -11.21), while other subgroups are effectively unimpaired. These findings delineate robust natural subdivisions within the ASC population that may allow for more individualized inferences and accelerate research towards precision medicine goals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.