ArticleJournal of neuroscience methods2016
Optical coherence tomography based microangiography provides an ability to longitudinally image arteriogenesis in vivo.
Article in Journal of neuroscience methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 12 citations in OpenAlex.
- Changes in retinal multilayer thickness and vascular network of patients with Alzheimer's disease.Biomedical engineering online · 2021Article
- Differences in cerebral blood vasculature and flow in awake and anesthetized mouse cortex revealed by quantitative optical coherence tomography angiography.Journal of neuroscience methods · 2021Article
- Longitudinal in-vivo OCM imaging of glioblastoma development in the mouse brain.Biomedical optics express · 2020Article
- EphA4/Tie2 crosstalk regulates leptomeningeal collateral remodeling following ischemic stroke.The Journal of clinical investigation · 2020Article
- Correlation of optical attenuation coefficient estimated using optical coherence tomography with changes in astrocytes and neurons in a chronic photothrombosis stroke model.Biomedical optics express · 2019Article
- Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis.American journal of physiology. Heart and circulatory physiology · 2019Article
- A modified rat model of hindlimb ischemia for augmentation and functional measurement of arteriogenesis.Journal of biological methods · 2018Article
- Capillary flow homogenization during functional activation revealed by optical coherence tomography angiography based capillary velocimetry.Scientific reports · 2018Article
- Temporal remodeling of pial collaterals and functional deficits in a murine model of ischemic stroke.Journal of neuroscience methods · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundArteriogenesis describes the active growth of the pre-existing collateral arterioles, which is a crucial tissue-saving process in occlusive vascular diseases. NEW
methodWe propose to use optical coherence tomography (OCT)-based microangiography (OMAG) to monitor arteriogenesis following artery transection in mouse ear and focal stroke in mouse brain.
resultsOur longitudinal mouse ear study shows that the growth phase of arteriogenesis, indicated by changes in collateral vessel diameter and velocity, occurs between 12 and 24h after vessel transection. Additionally, the magnitude of local inflammation is consistent with the time course of arteriogenesis, judging by the tissue thickness measurement and lymphatic vessel signals in OCT. In the mouse brain study, collateral vessel morphology, blood flow velocity and directionality are identified, and an activation of the collateral flow at the arteriolo-arteriolar anastomoses (AAA) is observed during stroke. COMPARISON WITH EXISTING
methodsIn comparison with histology and fluorescence imaging, OCT/OMAG is completely non-invasive and capable of producing consistent results of longitudinal changes in collateral vessel morphology and vasodynamics.
conclusionOCT/OMAG is a promising imaging tool for longitudinal study of collateral vessel remodeling in small animals. This technique can be applied in guiding the in vivo experiments of arteriogenesis stimulation to treat occlusive vascular diseases, including stroke.
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