Evidence map›Paper›PMID 27751860›Full record

ArticleMagnetic resonance imaging2017

Rapid and recoverable in vivo magnetic resonance imaging of the adult zebrafish at 7T.

Gavin D Merrifield, James Mullin, Lindsay Gallagher, Carl Tucker, Maurits A Jansen, Martin Denvir, William M Holmes

Abstract read
In one paragraph

Article in Magnetic resonance imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. New Enclosure forFrontiers in physiology · 2022
    Article
  8. Cerebrovascular development: mechanisms and experimental approaches.Cellular and molecular life sciences : CMLS · 2021
    Review
  9. Mechanisms ofJournal of cardiovascular development and disease · 2021
    Review
  10. Review
  11. Zebrafish Heart Failure Models.Frontiers in cell and developmental biology · 2021
    Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gavin D MerrifieldGlasgow Experimental MRI Centre, Institute of Neuroscience and Psychology, University of Glasgow, UK.
James MullinGlasgow Experimental MRI Centre, Institute of Neuroscience and Psychology, University of Glasgow, UK.
Lindsay GallagherGlasgow Experimental MRI Centre, Institute of Neuroscience and Psychology, University of Glasgow, UK.
Carl TuckerUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, UK.
Maurits A JansenUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, UK.
Martin DenvirUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, UK.
William M HolmesGlasgow Experimental MRI Centre, Institute of Neuroscience and Psychology, University of Glasgow, UK. Electronic address: william.holmes@glasgow.ac.uk.

Funding

British Heart Foundation NH/13/2/30347
6 · The paper itself

Abstract

Increasing scientific interest in the zebrafish as a model organism across a range of biomedical and biological research areas raises the need for the development of in vivo imaging tools appropriate to this subject. Development of the embryonic and early stage forms of the subject can currently be assessed using optical based techniques due to the transparent nature of the species at these early stages. However this is not an option during the juvenile and adult stages when the subjects become opaque. Magnetic resonance imaging (MRI) techniques would allow for the longitudinal and non-invasive assessment of development and health in these later life stages. However, the small size of the zebrafish and its aquatic environment represent considerable challenges for the technique. We have developed a suitable flow cell system that incorporates a dedicated MRI imaging coil to solve these challenges. The system maintains and monitors a zebrafish during a scan and allows for it to be fully recovered. The imaging properties of this system compare well with those of other preclinical MRI coils used in rodent models. This enables the rapid acquisition of MRI data which are comparable in terms of quality and acquisition time. This would allow the many unique opportunities of the zebrafish as a model organism to be combined with the benefits of non-invasive MRI.

Indexed as

Magnetic Resonance ImagingAnimalsCardiomyopathiesImage Processing, Computer-AssistedOxygenPhantoms, ImagingZebrafishOxygenFlow cellIn vivoMRIPhysiological monitoringSolenoidZebrafish

Identifiers

PMID27751860
PMCPMC5344283

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.