Evidence map›Paper›PMID 27751234›Full record

ArticleeLife2016

Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding.

Naiyan Chen, Hiroki Sugihara, Jinah Kim, Zhanyan Fu, Boaz Barak, Mriganka Sur, Guoping Feng, Weiping Han

Open access · goldAbstract read
In one paragraph

Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 115 citations in OpenAlex.

  1. Review
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  9. Review
  10. Article
  11. Article
  12. Hypothalamic neuronal-glial crosstalk in metabolic disease.npj metabolic health and disease · 2024
    Review
  13. Article
  14. Hypothalamic astrocyte NADNature communications · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Naiyan ChenLaboratory of Metabolic Medicine, Singapore Bioimaging Consortium, A*STAR, Singapore, Singapore.ORCID 0000-0002-4432-1805
Hiroki SugiharaDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
Jinah KimDepartment of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.
Zhanyan FuDepartment of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.
Boaz BarakDepartment of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.
Mriganka SurDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
Guoping FengDepartment of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0002-8021-277X
Weiping HanLaboratory of Metabolic Medicine, Singapore Bioimaging Consortium, A*STAR, Singapore, Singapore.
Agency for Science, Technology and Research · SGBroad Institute · USMassachusetts Institute of Technology · USMcGovern Institute for Brain Research · US

Funding

STRUCTURE AND FUNCTION IN THE RETINOGENICULATE PATHWAYR01EY007023 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUR, MRIGANKA · 1985 to 2018
$5.6M
Cortical representations and plasticity: Neurons and astrocytesR01EY018648 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SUR, MRIGANKA · 2007 to 2011
$2.5M
Cortical circuits and information flow during memory-guided perceptual decisionsU01NS090473 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SUR, MRIGANKA · 2014 to 2016
$2.4M
NEI NIH HHS R01 EY007023NEI NIH HHS R01 EY018648NINDS NIH HHS U01 NS090473
6 · The paper itself

Abstract

Multiple hypothalamic neuronal populations that regulate energy balance have been identified. Although hypothalamic glia exist in abundance and form intimate structural connections with neurons, their roles in energy homeostasis are less known. Here we show that selective Ca

Indexed as

Feeding BehaviorAnimalsArcuate Nucleus of HypothalamusCalcium SignalingGlial Fibrillary Acidic ProteinMiceNeurogliaGlial Fibrillary Acidic Proteinglial fibrillary astrocytic protein, mousearcuate nucleusfeedingglial cellmouseneuroscience

Identifiers

PMID27751234
PMCPMC5068968
OpenAlexW2533146972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.