ReviewProtein science : a publication of the Protein Society2017
Determination of the ribosome structure to a resolution of 2.5 Å by single-particle cryo-EM.
Review in Protein science : a publication of the Protein Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- A comprehensive foundation model for cryo-EM image processing.Nature methods · 2026Article
- Ribosomal Architecture and rRNA Modification Landscape in the Tick-Borne ParasitebioRxiv : the preprint server for biology · 2025Article
- NADK tetramer defective mutants affect lung cancer response to chemotherapy via controlling NADK activity.Genes & diseases · 2025Article
- Cryo-Electron Microscopy in the Study of Antiviral Innate Immunity.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Single-Particle Cryo-EM to Investigate Nonenveloped Virus-Like Particles.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Structural insights into the transporting and catalyzing mechanism of DltB in LTA D-alanylation.Nature communications · 2024Article
- Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.Nature communications · 2022Article
- Structural basis of the ligand binding and signaling mechanism of melatonin receptors.Nature communications · 2022Article
- Hierarchical natural move Monte Carlo refines flexible RNA structures into cryo-EM densities.RNA (New York, N.Y.) · 2020Article
- Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis.Scientific reports · 2020Article
- The 23S Ribosomal RNA FromFrontiers in microbiology · 2020Article
- Methylation of Ribosomal RNA: A Mitochondrial Perspective.Frontiers in genetics · 2020Review
- Joachim Frank's Binding with the Ribosome.Structure (London, England : 1993) · 2019Review
- New Insights into Ribosome Structure and Function.Cold Spring Harbor perspectives in biology · 2019Review
- On the damage done to the structure of the Thermoplasma acidophilum proteasome by electron radiation.Protein science : a publication of the Protein Society · 2018Article
- Article
- Cryo-EM in drug discovery: achievements, limitations and prospects.Nature reviews. Drug discovery · 2018Review
- How Messenger RNA and Nascent Chain Sequences Regulate Translation Elongation.Annual review of biochemistry · 2018Review
- Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy.The Journal of physiology · 2018Review
- Emerging Roles of Mitochondrial Ribosomal Proteins in Plant Development.International journal of molecular sciences · 2017Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
With the advance of new instruments and algorithms, and the accumulation of experience over decades, single-particle cryo-EM has become a pivotal part of structural biology. Recently, we determined the structure of a eukaryotic ribosome at 2.5 Å for the large subunit. The ribosome was derived from Trypanosoma cruzi, the protozoan pathogen of Chagas disease. The high-resolution density map allowed us to discern a large number of unprecedented details including rRNA modifications, water molecules, and ions such as Mg
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