Evidence map›Paper›PMID 27750392›Full record

ArticleJournal of biomedical materials research. Part A2017

The clinical, radiological, microbiological, and molecular profile of the skin-penetration site of transfemoral amputees treated with bone-anchored prostheses.

Maria Lennerås, Georgios Tsikandylakis, Margarita Trobos, Omar Omar, Forugh Vazirisani, Anders Palmquist, Örjan Berlin, Rickard Brånemark, Peter Thomsen

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06310239 (Osseointegrated Limb Implant Microbiome Population Adaptation Study), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06310239 recruitingnot on this mapstarted 2023, after this paper: background citation

Osseointegrated Limb Implant Microbiome Population Adaptation Study

Typeobservational_patient_registrySponsorWalter Reed National Military Medical CenterRan2023 to 2029Enrolled50ConditionsAmputation With OsseointegrationArmsCollection of biologic samples and data
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Achieving stomal continence with an ileal pouch and a percutaneous implant.Journal of materials science. Materials in medicine · 2022
    Article
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  11. Review
  12. Review
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  19. The clinical outcome and microbiological profile of bone-anchored hearing systems (BAHS) with different abutment topographies: a prospective pilot study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Maria LenneråsDepartment of Biomaterials, Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg, Gothenburg, SE-405 30, Sweden Box 412.
Georgios TsikandylakisBIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, SE-405 30, Sweden Box 412.
Margarita TrobosDepartment of Biomaterials, Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg, Gothenburg, SE-405 30, Sweden Box 412.
Omar OmarDepartment of Biomaterials, Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg, Gothenburg, SE-405 30, Sweden Box 412.
Forugh VazirisaniDepartment of Biomaterials, Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg, Gothenburg, SE-405 30, Sweden Box 412.
Anders PalmquistDepartment of Biomaterials, Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg, Gothenburg, SE-405 30, Sweden Box 412.
Örjan BerlinBIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, SE-405 30, Sweden Box 412.
Rickard BrånemarkBIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, SE-405 30, Sweden Box 412.
Peter ThomsenDepartment of Biomaterials, Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg, Gothenburg, SE-405 30, Sweden Box 412.
University of Gothenburg · SESahlgrenska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The breach of the skin barrier is a critical issue associated with the treatment of individuals with transfemoral amputation (TFA) using osseointegrated, percutaneous titanium implants. Thirty TFA patients scheduled for abutment exchange or removal were consecutively enrolled. The aims were to determine the macroscopic skin signs, the presence of bacteria and the gene expression in abutment-adherent cells and to conduct correlative and comparative analyses between the different parameters. Redness and a granulation ring were present in 47% of the patients. Bacteria were detected in 27/30 patients, commonly in the bone canal. Staphylococcus aureus, coagulase-negative staphylococci, streptococci, and Enterococcus faecalis were the most common. A positive correlation was found between TNF-α expression and the detection of S. aureus. Staphylococcus aureus together with other bacterial species revealed a positive relationship with MMP-8 expression. A negative correlation was demonstrated between the length of the residual femur bone and the detection of a granulation ring and E. faecalis. A positive correlation was revealed between fixture loosening and pain and the radiological detection of endosteal bone resorption. Fixture loosening was also correlated with the reduced expression of interleukin-10 and osteocalcin. It is concluded that several relationships exist between clinical, radiological, microbiological, and molecular assessments of the percutaneous area of TFAs. Further long term studies on larger patient cohorts are required to determine the precise cause-effect relationships and unravel the role of host-bacteria interactions in the skin, bone canal and on the abutment for the longevity of percutaneous implants as treatment of TFA. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 578-589, 2017.

Indexed as

AmputeesEnterococcus faecalisFemurStaphylococcal InfectionsStaphylococcus aureusAdultAgedBone-Implant InterfaceCross-Sectional StudiesFemaleHumansInterleukin-10Interleukin-8MaleMiddle AgedOsteocalcinCXCL8 protein, humanIL10 protein, humanInterleukin-10Interleukin-8Osteocalcingene expressioninfectionosseointegrationpercutaneoustransfemoral amputees

Identifiers

PMID27750392
PMCPMC5216444
OpenAlexW2538726634

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.