Evidence map›Paper›PMID 27750374›Full record

ReviewAnnals of the New York Academy of Sciences2016

Advances in biologic augmentation for rotator cuff repair.

Sahishnu Patel, Anthony P Gualtieri, Helen H Lu, William N Levine

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of the New York Academy of Sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03091075 (Ability of Oral Steroid), which is not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03091075 naterminatednot on this mapstarted 2018, after this paper: background citation

Ability of Oral Steroid (Oxandrolone) to Halt Fatty Infiltration and Aid Rotator Cuff Healing: A Double-Blind, Randomized Clinical Trial

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2018 to 2026Enrolled4ConditionsRotator Cuff TearArmsOxandrolone, Placebo
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. A novel and efficient murine model for investigating tendon-to-bone healing.Journal of orthopaedic surgery and research · 2024
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  20. Muscle degeneration in chronic massive rotator cuff tears of the shoulder: Addressing the real problem using a graphene matrix.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sahishnu PatelBiomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York.
Anthony P GualtieriDepartment of Orthopedic Surgery, New York Presbyterian/Columbia University Medical Center, New York, New York.
Helen H LuBiomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York.
William N LevineDepartment of Orthopedic Surgery, New York Presbyterian/Columbia University Medical Center, New York, New York.

Funding

Interface Tissue Engineering for Soft Tissue-to-Bone IntegrationR01AR055280 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LU, HELEN H · 2008 to 2014
$1.9M
NIAMS NIH HHS R01 AR055280
6 · The paper itself

Abstract

Rotator cuff tear is a very common shoulder injury that often necessitates surgical intervention for repair. Despite advances in surgical techniques for rotator cuff repair, there is a high incidence of failure after surgery because of poor healing capacity attributed to many factors. The complexity of tendon-to-bone integration inherently presents a challenge for repair because of a large biomechanical mismatch between the tendon and bone and insufficient regeneration of native tissue, leading to the formation of fibrovascular scar tissue. Therefore, various biological augmentation approaches have been investigated to improve rotator cuff repair healing. This review highlights recent advances in three fundamental approaches for biological augmentation for functional and integrative tendon-bone repair. First, the exploration, application, and delivery of growth factors to improve regeneration of native tissue are discussed. Second, applications of stem cell and other cell-based therapies to replenish damaged tissue for better healing are covered. Finally, this review will highlight the development and applications of compatible biomaterials to both better recapitulate the tendon-bone interface and improve delivery of biological factors for enhanced integrative repair.

Indexed as

AnimalsBiological ProductsHumansIntercellular Signaling Peptides and ProteinsRotator Cuff InjuriesStem Cell TransplantationTissue ScaffoldsBiological ProductsIntercellular Signaling Peptides and Proteinsbiological augmentationbiomaterialsgrowth factorsrotator cuff repairstem cell therapies

Identifiers

PMID27750374
PMCPMC5221413

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.