ArticleAnnals of internal medicine2017
Chronic Hepatitis B and C Virus Infection and Risk for Non-Hodgkin Lymphoma in HIV-Infected Patients: A Cohort Study.
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Article in Annals of internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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25citing papers in PubMed, 1 pooled it
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Hepatitis C virus infection is a risk factor for non-Hodgkin lymphoma: A MOOSE-compliant meta-analysis.Medicine · 2019Pooled it
- Higher rates of HBsAg clearance with tenofovir-containing therapy in HBV/HIV co-infection.PloS one · 2019Trial
- Long-Term Survival in an Elderly HCV Patient with Double Primary Malignant Tumors Managed with Local Therapy Only.OncoTargets and therapy · 2026Article
- Risk of lymphoma among people with HIV in the United States, 2001-2019.Journal of the National Cancer Institute · 2025Article
- Current State of AIDS-Related Malignant Lymphoma.Viruses · 2025Review
- Retrospective analysis of HIV-associated lymphomas: insights from a single Romanian center over 15 years.Frontiers in oncology · 2025Article
- Virus-driven dysregulation of the BCR pathway: a potential mechanism for the high prevalence of HIV related B-cell lymphoma.Annals of hematology · 2024Review
- Human immunodeficiency virus-associated Lymphomas: EHA-ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.HemaSphere · 2024Article
- Changing Prevalence of AIDS and Non-AIDS-Defining Cancers in an Incident Cohort of People Living with HIV over 28 Years.Cancers · 2023Article
- Hepatitis C coinfection and extrahepatic cancer incidence among people living with HIV.HIV medicine · 2022Article
- [Clinical characteristics and prognostic features of 63 HIV-associated diffuse large B-cell lymphoma: a single-center real-world study in China].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2022Article
- Risk of Non-Hodgkin Lymphoma among Patients with Hepatitis B Virus and Hepatitis C Virus in Taiwan: A Nationwide Cohort Study.Cancers · 2022Article
- How immunodeficiency can lead to malignancy.Hematology. American Society of Hematology. Education Program · 2021Article
- Cancer incidence and risk factors in dialysis patients with human immunodeficiency virus: a cohort study.Clinical kidney journal · 2021Article
- Epidemiology of haematological malignancies in people living with HIV.The lancet. HIV · 2020Review
- Optimizing treatment of HIV-associated lymphoma.Blood · 2019Review
- The clinical features and prognosis of 100 AIDS-related lymphoma cases.Scientific reports · 2019Article
- Serological Assessment of 18 Pathogens and Risk of AIDS-Associated Non-Hodgkin Lymphoma.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Increased risk of anal squamous cell carcinoma in HIV-positive men with prior hepatitis B virus infection.AIDS (London, England) · 2019Article
- Non-Hodgkin lymphoma risk in adults living with HIV across five continents.AIDS (London, England) · 2018Article
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23 authors at 5 institutions in 4 countries.
Qing WangFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Andrea De LucaFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Colette SmithFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Robert ZangerleFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Helen SambatakouFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Fabrice BonnetFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Colette SmitFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Philipp SchommersFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Alicia ThorntonFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Juan BerenguerFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Lars PetersFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Vincenzo SpagnuoloFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Adriana AmmassariFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Andrea AntinoriFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Eugenia Quiros-RoldanFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Cristina MussiniFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Jose M MiroFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Deborah KonopnickiFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Jan FehrFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Maria A CampbellFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Monique TermoteFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Heiner C BucherFrom Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland; University of Siena, Siena, Italy; University College London, London, United Kingdom; Innsbruck Medical University, Innsbruck, Austria; University of Athens, Athens, Greece; Université Bordeaux, Bordeaux, France; Stichting HIV Monitoring, Amsterdam, the Netherlands; University Hospital of Cologne, Cologne, Germany; Hospital General Universitario Gregorio Marañón, Madrid, Spain; Rigshospitalet, Copenhagen, Denmark; IRCCS Ospedale San Raffaele, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Modena and Reggio Emilia, Modena, Italy; University of Barcelona, Barcelona, Spain; Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; and University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Hepatitis Coinfection and Non Hodgkin Lymphoma project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord
Innsbruck Medical University · ATNational and Kapodistrian University of Athens · GRUniversity of Siena · ITUniversity College Hospital · GBUniversity College London · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Non-Hodgkin lymphoma (NHL) is the most common AIDS-defining condition in the era of antiretroviral therapy (ART). Whether chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection promote NHL in HIV-infected patients is unclear. Objective: To investigate whether chronic HBV and HCV infection are associated with increased incidence of NHL in HIV-infected patients. Design: Cohort study. Setting: 18 of 33 cohorts from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE). Patients: HIV-infected patients with information on HBV surface antigen measurements and detectable HCV RNA, or a positive HCV antibody test result if HCV RNA measurements were not available. Measurements: Time-dependent Cox models to assess risk for NHL in treatment-naive patients and those initiating ART, with inverse probability weighting to control for informative censoring. Results: A total of 52 479 treatment-naive patients (1339 [2.6%] with chronic HBV infection and 7506 [14.3%] with HCV infection) were included, of whom 40 219 (77%) later started ART. The median follow-up was 13 months for treatment-naive patients and 50 months for those receiving ART. A total of 252 treatment-naive patients and 310 treated patients developed NHL, with incidence rates of 219 and 168 cases per 100 000 person-years, respectively. The hazard ratios for NHL with HBV and HCV infection were 1.33 (95% CI, 0.69 to 2.56) and 0.67 (CI, 0.40 to 1.12), respectively, in treatment-naive patients and 1.74 (CI, 1.08 to 2.82) and 1.73 (CI, 1.21 to 2.46), respectively, in treated patients. Limitation: Many treatment-naive patients later initiated ART, which limited the study of the associations of chronic HBV and HCV infection with NHL in this patient group. Conclusion: In HIV-infected patients receiving ART, chronic co-infection with HBV and HCV is associated with an increased risk for NHL. Primary Funding Source: European Union Seventh Framework Programme.
Indexed as
AdultAnti-HIV AgentsBiomarkersCohort StudiesFemaleHepatitis AntibodiesHepatitis B, ChronicHepatitis B Core AntigensHepatitis B Surface AntigensHepatitis CHepatitis C, ChronicHIV InfectionsHumansImmunoglobulin GLymphoma, Non-HodgkinMaleAnti-HIV AgentsBiomarkersHepatitis AntibodiesHepatitis B Core AntigensHepatitis B Surface AntigensImmunoglobulin GRNA, Viral
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