Evidence map›Paper›PMID 27750183›Full record

ArticleDrug and alcohol dependence2016

Risky driving and sexual behaviors as developmental outcomes of co-occurring substance use and antisocial behavior.

Jeremy W Luk, Matthew J Worley, Evan Winiger, Ryan S Trim, Christian J Hopfer, John K Hewitt, Sandra A Brown, Tamara L Wall

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Utilizing Machine Learning for Predicting PrEP Use Status Among Sexual and Gender Minority Young Adults.Prevention science : the official journal of the Society for Prevention Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jeremy W LukDepartment of Psychiatry, University of California, San Diego, United States. Electronic address: j2luk@ucsd.edu.
Matthew J WorleyDepartment of Psychiatry, University of California, San Diego, United States; V.A. San Diego Health System, La Jolla, United States.
Evan WinigerDepartment of Psychiatry, University of California, San Diego, United States.
Ryan S TrimDepartment of Psychiatry, University of California, San Diego, United States; V.A. San Diego Health System, La Jolla, United States.
Christian J HopferDepartment of Psychiatry, University of Colorado, Denver, United States.
John K HewittInstitute for Behavioral Genetics, University of Colorado, Boulder, United States.
Sandra A BrownDepartment of Psychiatry, University of California, San Diego, United States.
Tamara L WallDepartment of Psychiatry, University of California, San Diego, United States; V.A. San Diego Health System, La Jolla, United States. Electronic address: twall@ucsd.edu.

Funding

Twin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5M
Alcohol Research in the Science/Practitioner ModelT32AA013525 · NIAAA · SAN DIEGO STATE UNIVERSITY · PI EDWARD P RILEY, ANDREA SPADONI TOWNSEND · 2002 to 2026
$8.4M
GENETICS OF ADOLESCENT ANTISOCIAL DRUG DEPENDENCER01DA012845 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 2000 to 2012
$7.1M
Genetics and Progression of Early-onset Substance Dependence and HIV RiskR01DA035804 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HOPFER, CHRISTIAN J, STALLINGS, MICHAEL CRAIG · 2014 to 2018
$4.9M
ADOLESCENT ALCOHOL TREATMENT OUTCOME--RECOVERY PATTERNSR37AA007033 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, SANDRA A · 1999 to 2008
$4.6M
Genetics of Adolescent Antisocial Drug DependenceR01DA021913 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HOPFER, CHRISTIAN J · 2008 to 2013
$2.9M
A family study of substance use &coonduct disorderR01DA015522 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HOPFER, CHRISTIAN J · 2003 to 2007
$2.6M
Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders ResearchK24DA032555 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HOPFER, CHRISTIAN J · 2013 to 2022
$1.9M
Genetics of Adolescent Antisocial Drug DependenceR01DA021905 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WALL, TAMARA L · 2008 to 2012
$1.9M
Behavioral economic mechanisms of prescription opioid addiction in chronic painK23DA039348 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WORLEY, MATTHEW J. · 2016 to 2020
$1.0M
Mediators of Outpatient Treatment for Comorbid Substance Use Disorder and Major DF31DA030861 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WORLEY, MATTHEW J. · 2011 to 2012
$66k
NIAAA NIH HHS R37 AA007033NIAAA NIH HHS T32 AA013525NIDA NIH HHS F31 DA030861NIDA NIH HHS K23 DA039348NIDA NIH HHS K24 DA032555NIDA NIH HHS L30 DA038321NIDA NIH HHS P60 DA011015NIDA NIH HHS R01 DA012845NIDA NIH HHS R01 DA015522NIDA NIH HHS R01 DA021905NIDA NIH HHS R01 DA021913NIDA NIH HHS R01 DA035804
6 · The paper itself

Abstract

purposeTo examine the associations between substance use and antisocial behavior trajectories and seven risky behaviors over time.

methodData were collected from a high-risk sample of adolescents followed into young adulthood. Five trajectory classes, identified based on dual development of substance use and antisocial behavior symptoms, were used to predict three risky driving and four risky sexual behaviors.

resultsIn this high-risk sample (n=530), participants reported notably high overall rates of reckless driving (55.5%) and unprotected sex under the influence (44.8%) in the past year. Risky behaviors that are typically of low base rates in population-based studies were also elevated, with 8.8% reporting past-year driving under the influence (DUI) charge, 17.6% reporting lifetime sexually transmitted infection (STI), and 10.4% reporting lifetime injection drug use. The Dual Chronic class had the highest levels of all seven risky behaviors, and were 3-4 times more likely to report risky driving, lifetime STI, and injection drug use than the Relatively Resolved class. Rates of past-year reckless driving and DUI were elevated among classes with persistent antisocial behavior, whereas rates of DUI, DUI charge, and unprotected sex under the influence were elevated among classes with persistent substance use.

conclusionsYoung adults with persistent co-occurring substance use and antisocial behavior engage in multiple very costly risky behaviors. Differential associations between risky behaviors and trajectory classes highlight the need for targeted interventions.

Indexed as

Risk-TakingAdultAntisocial Personality DisorderAutomobile DrivingFemaleHumansMaleModels, PsychologicalSexual BehaviorSexually Transmitted DiseasesSubstance Abuse, IntravenousSubstance-Related DisordersUnsafe SexYoung AdultAntisocial behaviorInjection drug useRisky drivingSexual transmitted infectionsSubstance use

Identifiers

PMID27750183
PMCPMC5140786

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.