ArticleThyroid : official journal of the American Thyroid Association2017
Variable Cold-Induced Brown Adipose Tissue Response to Thyroid Hormone Status.
Article in Thyroid : official journal of the American Thyroid Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Brown Adipose Tissue (BAT) detection byEndocrine · 2018Pooled it
- Resting Energy Expenditure and Cold-induced Thermogenesis in Patients With Overt Hyperthyroidism.The Journal of clinical endocrinology and metabolism · 2022Trial
- Metabolic effects of brown fat in transitioning from hyperthyroidism to euthyroidism.European journal of endocrinology · 2021Trial
- Thermogenic Gene Expression in Human Neck Adipose Tissue in Relation to Circulating and Local Thyroid Hormone Levels.Journal of the Endocrine Society · 2026Article
- A Study on the Effects of Hypothyroidism on the Senses: A Comprehensive Narrative Review.Cureus · 2024Review
- Temperature Differences Between Controlled Primary Hypothyroidism and Healthy Patients: An Exploratory Study.Journal of the Endocrine Society · 2024Article
- Brown Adipose Tissue-A Translational Perspective.Endocrine reviews · 2023Review
- BMP8 and activated brown adipose tissue in human newborns.Nature communications · 2021Article
- Towards an understanding of the mechanoreciprocity process in adipocytes and its perturbation with aging.Mechanisms of ageing and development · 2021Review
- Activated brown adipose tissue and its relationship to adiposity and metabolic markers: an exploratory study.Adipocyte · 2020Article
- Thyroid hormones in diabetes, cancer, and aging.Aging cell · 2020Review
- Thermogenesis in Adipose Tissue Activated by Thyroid Hormone.International journal of molecular sciences · 2020Review
- Uncoupling of sarcoendoplasmic reticulum calcium ATPase pump activity by sarcolipin as the basis for muscle non-shivering thermogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Investigation of the Relationship between MR-Based Supraclavicular Fat Fraction and Thyroid Hormones.Obesity facts · 2020Article
- Resolution of Hypothyroidism Restores Cold-Induced Thermogenesis in Humans.Thyroid : official journal of the American Thyroid Association · 2019Observational
- Brown and Brite: The Fat Soldiers in the Anti-obesity Fight.Frontiers in physiology · 2019Review
- TRH Neurons and Thyroid Hormone Coordinate the Hypothalamic Response to Cold.European thyroid journal · 2018Review
- Brown Adipose Tissue Energy Metabolism in Humans.Frontiers in endocrinology · 2018Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn addition to its role in adaptive thermogenesis, brown adipose tissue (BAT) may protect from weight gain, insulin resistance/diabetes, and metabolic syndrome. Prior studies have shown contradictory results regarding the influence of thyroid hormone (TH) levels on BAT volume and activity. The aim of this pilot study was to gain further insights regarding the effect of TH treatment on BAT function in adult humans by evaluating the BAT mass and activity prospectively in six patients, first in the hypothyroid and then in the thyrotoxic phase.
methodsThe study subjects underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) scanning after cold exposure to measure BAT mass and activity while undergoing treatment for differentiated thyroid cancer, first while hypothyroid following TH withdrawal at the time of the radioactive iodine treatment and then three to six months after starting TH suppressive treatment when they were iatrogenically thyrotoxic. Thermogenic and metabolic parameters were measured in both phases.
resultsAll study subjects had detectable BAT under cold stimulation in both the hypothyroid and thyrotoxic state. The majority but not all (4/6) subjects showed an increase in detectable BAT volume and activity under cold stimulation between the hypothyroid and thyrotoxic phase (total BAT volume: 72.0 ± 21.0 vs. 87.7 ± 16.5 mL, p = 0.25; total BAT activity 158.1 ± 72.8 vs. 189.0 ± 55.5 SUV*g/mL, p = 0.34). Importantly, circulating triiodothyronine was a stronger predictor of energy expenditure changes compared with cold-induced BAT activity.
conclusionsIatrogenic hypothyroidism lasting two to four weeks does not prevent cold-induced BAT activation, while the use of TH to induce thyrotoxicosis does not consistently increase cold-induced BAT activity. It remains to be determined which physiological factors besides TH play a role in regulating BAT function.
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