ArticleNature genetics2016
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
Open access · greenAbstract readComparative Study
In one paragraph
Article in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 8 pooled it
15.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
151 citing papers in PubMed, 8 syntheses or guidelines pooled it, 250 citations in OpenAlex.
- Pooled it
- A genome-wide association study of buccal mucosa cancer in India and multi-ancestry meta-analysis discovers risk loci and gene-environment interactions.EBioMedicine · 2025Pooled it
- Investigating causal links between gallstones, cholecystectomy, and 33 site-specific cancers: a Mendelian randomization post-meta-analysis study.BMC cancer · 2024Pooled it
- Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study.BMC oral health · 2023Pooled it
- Causal association between inflammatory bowel disease and 32 site-specific extracolonic cancers: a Mendelian randomization study.BMC medicine · 2023Pooled it
- Causal effects of education attainment on oral and oropharyngeal cancer: New evidence from a meta-analysis and Mendelian randomization study.Frontiers in public health · 2023Pooled it
- Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers.PLoS genetics · 2021Pooled it
- Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.Gastroenterology · 2019Pooled it
- Genetic susceptibility, risk prediction, and druggable targets for oropharyngeal cancer: a UK Biobank study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Unveiling the association between plasma lipid species and pan-cancers: A bidirectional 2-sample Mendelian randomization study.Medicine · 2026Article
- Associations of combined lifestyle and genetic risk with incident head and neck cancer: a prospective study in the UK Biobank.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Multi-Omics Profiling Identifies Novel Therapeutic Targets and Pathobiological Mechanisms in Oral Cancer.Journal of cellular and molecular medicine · 2026Article
- Genomic structural equation modelling of 12 cancers identifies a latent pan-cancer susceptibility factor and shared determinants of carcinogenesis.EBioMedicine · 2026Article
- Combining Mendelian randomization and multiomics data to determine the causal relationship between systemic inflammation and head and neck squamous cell carcinoma.Cancer cell international · 2026Article
- Genome-wide association study of never-smoking non-drinking young adults developing oral squamous cell carcinoma.BMC cancer · 2026Article
- Association between immune cells and multiple cancers: Insights from Mendelian randomization and gene-based analysis.iScience · 2026Article
- Immune Cell Profiles and Novel Insights Into Cancer Risk: A Focus on Oral and Pharyngeal Cancer.Human mutation · 2026Article
- Divergent immuno-landscapes: comparing the tumor microenvironment of Indian and Western HNSCC patients.Frontiers in cell and developmental biology · 2026Review
- Evaluating the causal relationship between sex hormones and oral cavity cancer: a Mendelian randomization study.Archives of medical science : AMS · 2026Article
- Exploring genetic diversity in genome-wide association studies and polygenic risk scores in the admixed Brazilian population.Genetics and molecular biology · 2026Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
54 authors at 20 institutions in 19 countries.
Corina LesseurInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.
Brenda DiergaardeDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Andrew F OlshanDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Victor Wünsch-FilhoFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil.
Andrew R NessNational Institute for Health Research (NIHR) Biomedical Research Unit in Nutrition, Diet and Lifestyle at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK.
Geoffrey LiuPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Martin LackoDepartment of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, the Netherlands.
José Eluf-NetoDepartamento de Medicina Preventiva, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Silvia FranceschiInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.
Pagona LagiouDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Gary J MacfarlaneSchool of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
Lorenzo RichiardiDepartment of Medical Sciences, University of Turin, Turin, Italy.
Stefania BocciaSection of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, Fondazione Policlinico 'Agostino Gemelli', Rome, Italy.
Jerry PoleselUnit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Aviano, Italy.
Kristina KjaerheimCancer Registry of Norway, Oslo, Norway.
David ZaridzeDepartment of Cancer Epidemiology and Prevention, Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Centre of the Russian Ministry of Health, Moscow, Russian Federation.
Mattias JohanssonInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.
Ana M MenezesPrograma de Pós-Graduacão em Epidemiologia, Universidade Federal de Pelotas (UFPel), Pelotas, Brazil.
Maria Paula CuradoEpidemiology, International Center for Research (CIPE), A.C. Camargo Cancer Center, Sao Paulo, Brazil.
Max RobinsonCentre for Oral Health Research, Newcastle University, Newcastle, UK.
Wolfgang AhrensLeibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Cristina CanovaDeparment of Molecular Medicine, University of Padova, Padova, Italy.
Ariana ZnaorInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.
Xavier CastellsaguéInstitut Català d'Oncologia (ICO)-IDIBELL, CIBERESP, l'Hospitalet de Llobregat, Barcelona, Spain.
David I ConwaySchool of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK.
Ivana HolcátováInstitute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Dana MatesNational Institute of Public Health, Bucharest, Romania.
Marta VilenskyInstituto de Oncología 'Angel H. Roffo', Universidad de Buenos Aires, Buenos Aires, Argentina.
Claire M HealyTrinity College School of Dental Science, Dublin, Ireland.
Neonila Szeszenia-DąbrowskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
Eleonóra FabiánováRegional Authority of Public Health, Banská Bystrica, Slovakia.
Jolanta LissowskaMaria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology (MCMCC), Warsaw, Poland.
Jennifer R GrandisDepartment of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA.
Mark C WeisslerDepartment of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Eloiza H TajaraDepartment of Molecular Biology, School of Medicine of São José do Rio Preto, São José do Rio Preto, Brazil.
Fabio D NunesDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Marcos B de CarvalhoDepartment of Head and Neck Surgery, Heliópolis Hospital, São Paulo, Brazil.
Steve ThomasSchool of Oral and Dental Sciences, University of Bristol, Bristol, UK.
Rayjean J HungLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Wilbert H M PetersDepartment of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
Rolando HerreroInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.
Gabriella CadoniInstitute of Otorhinolaryngology, Università Cattolica del Sacro Cuore, Fondazione Policlinico 'Agostino Gemelli', Rome, Italy.
H Bas Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Annika SteffenGerman Institute of Human Nutrition in Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
Antonio AgudoUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO)-IDIBELL, l'Hospitalet de Llobregat, Barcelona, Spain.
Oxana ShanginaDepartment of Cancer Epidemiology and Prevention, Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Centre of the Russian Ministry of Health, Moscow, Russian Federation.
Xiangjun XiaoDepartment of Biomedical Data Sciences, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Valérie GaborieauInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.
Amélie ChabrierInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.
Devasena AnantharamanInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.
Paolo BoffettaTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Christopher I AmosDepartment of Biomedical Data Sciences, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
James D McKayInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.
Paul BrennanInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.
Centre International de Recherche sur le Cancer · FRDartmouth College · USInstitut Català d'Oncologia · ESMinistry of Health of the Russian Federation · RUUniversità Cattolica del Sacro Cuore · ITAC Camargo Hospital · BRCancer Registry of Norway · NOCentro di Riferimento Oncologico · ITCharles University · CZFaculdade de Medicina de São José do Rio Preto · BRGerman Institute of Human Nutrition · DEHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRHospital Heliópolis · BRHrvatski zavod za javno zdravstvo · HRIcahn School of Medicine at Mount Sinai · USImperial College London · GBInstituto de Saúde · BRLeibniz Institute for Prevention Research and Epidemiology - BIPS · DELunenfeld-Tanenbaum Research Institute · CAMaastricht University · NL
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MVECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0MTranslational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3MWILD TYPE P53-BASED ADJUVANT IMMUNOTHERAPY FOR SCCHNP50CA097190 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 2004 to 2026
$49.6MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MGene Environment Interaction in Head and Neck CancerR01CA090731 · NCI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI OLSHAN, ANDREW · 2001 to 2005
$4.6MGENETICS OF TOBACCO AND ALCOHOL RELATED CANCERSR01CA092039 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI BRENNAN, PAUL JOSEPH · 2003 to 2010
$3.6MDepartment of Health RP-PG-0707-10034Medical Research Council MR/N005872/1NCI NIH HHS P30 CA016086NCI NIH HHS P30 CA023108NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA097190NCI NIH HHS R01 CA090731NCI NIH HHS R01 CA092039NCI NIH HHS U19 CA148127NIEHS NIH HHS P30 ES010126World Health Organization 001
Abstract
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyAgedCase-Control StudiesFemaleGenetic MarkersGenetic VariationHaplotypesHLA AntigensHumansMaleMiddle AgedMouthMouth NeoplasmsPapillomaviridaePapillomavirus InfectionsGenetic MarkersHLA Antigens
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