ArticleNature neuroscience2016
Synaptic scaling rule preserves excitatory-inhibitory balance and salient neuronal network dynamics.
Article in Nature neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 187 citations in OpenAlex.
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- Emergence of sparse coding, balance and decorrelation from a biologically-grounded spiking neural network model of learning in the primary visual cortex.PLoS computational biology · 2025Article
- Interleaving asynchronous and synchronous activity in balanced cortical networks with short term synaptic depression.Nature communications · 2025Article
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- Excitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics.PLoS computational biology · 2025Article
- Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics.Nature communications · 2024Article
- Structural influences on synaptic plasticity: The role of presynaptic connectivity in the emergence of E/I co-tuning.PLoS computational biology · 2024Article
- ZCCHC17 knockdown phenocopies Alzheimer's disease-related loss of synaptic proteins and hyperexcitability.Journal of neuropathology and experimental neurology · 2024Article
- Distributed and dynamical communication: a mechanism for flexible cortico-cortical interactions and its functional roles in visual attention.Communications biology · 2024Article
- Assessment of the excitation-inhibition ratio in the Fmr1 KO2 mouse using neuronal oscillation dynamics.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Ensemble learning and ground-truth validation of synaptic connectivity inferred from spike trains.PLoS computational biology · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The balance between excitation and inhibition (E-I balance) is maintained across brain regions though the network size, strength and number of synaptic connections, and connection architecture may vary substantially. We use a culture preparation to examine the homeostatic synaptic scaling rules that produce E-I balance and in vivo-like activity. We show that synaptic strength scales with the number of connections K as ∼ , close to the ideal theoretical value. Using optogenetic techniques, we delivered spatiotemporally patterned stimuli to neurons and confirmed key theoretical predictions: E-I balance is maintained, active decorrelation occurs and the spiking correlation increases with firing rate. Moreover, the trial-to-trial response variability decreased during stimulation, as observed in vivo. These results-obtained in generic cultures, predicted by theory and observed in the intact brain-suggest that the synaptic scaling rule and resultant dynamics are emergent properties of networks in general.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.