ArticleNature cell biology2016
Amnioserosa cell constriction but not epidermal actin cable tension autonomously drives dorsal closure.
Article in Nature cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Who cites it
45 citing papers in PubMed, 91 citations in OpenAlex.
- Adhesion to a common ECM mediates interdependence in tissue morphogenesis in Drosophila.EMBO reports · 2026Article
- Supracellular actomyosin assemblies: master coordinators of development.Development (Cambridge, England) · 2025Review
- Automorphy as a self-organizing DPP-dependent process that translates patterns into mechanical programs duringScience advances · 2025Article
- Vertex models capturing subcellular scales in epithelial tissues.PLoS computational biology · 2025Review
- A transient contractile seam promotes epithelial sealing and sequential assembly of body segments.Nature communications · 2025Article
- Dynamic interplay of microtubule and actomyosin forces drive tissue extension.Nature communications · 2024Article
- Elimination of aberrantly specified cell clones is independent of interfacial Myosin II accumulation.Journal of cell science · 2023Article
- How dynamic prestress governs the shape of living systems, from the subcellular to tissue scale.Interface focus · 2022Review
- Engineered kinases as a tool for phosphorylation of selected targets in vivo.The Journal of cell biology · 2022Article
- Superresolution microscopy reveals actomyosin dynamics in medioapical arrays.Molecular biology of the cell · 2022Article
- SCAR/WAVE complex recruitment to a supracellular actomyosin cable by myosin activators and a junctional Arf-GEF duringMolecular biology of the cell · 2022Article
- Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo.Development (Cambridge, England) · 2022Article
- Proximate larval epidermal cell layer generates forces for Pupal thorax closure in Drosophila.Genetics · 2022Article
- A Comparative Study of the Role of Formins inCells · 2022Article
- Force measurements of Myosin II waves at the yolk surface during Drosophila dorsal closure.Biophysical journal · 2022Article
- The Lateral Epidermis Actively Counteracts Pulling by the Amnioserosa During Dorsal Closure.Frontiers in cell and developmental biology · 2022Article
- Septate junction proteins are required for cell shape changes, actomyosin reorganization and cell adhesion during dorsal closure inFrontiers in cell and developmental biology · 2022Article
- Crosstalk between basal extracellular matrix adhesion and building of apical architecture during morphogenesis.Biology open · 2021Review
- Article
- Force-mediated cellular anisotropy and plasticity dictate the elongation dynamics of embryos.Science advances · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue morphogenesis requires coordination of multiple force-producing components. During dorsal closure in fly embryogenesis, an epidermis opening closes. A tensioned epidermal actin/MyosinII cable, which surrounds the opening, produces a force that is thought to combine with another MyosinII force mediating apical constriction of the amnioserosa cells that fill the opening. A model proposing that each force could autonomously drive dorsal closure was recently challenged by a model in which the two forces combine in a ratchet mechanism. Acute force elimination via selective MyosinII depletion in one or the other tissue shows that the amnioserosa tissue autonomously drives dorsal closure while the actin/MyosinII cable cannot. These findings exclude both previous models, although a contribution of the ratchet mechanism at dorsal closure onset remains likely. This shifts the current view of dorsal closure being a combinatorial force-component system to a single tissue-driven closure event.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.