ArticleNature cell biology2016
The actin cable is dispensable in directing dorsal closure dynamics but neutralizes mechanical stress to prevent scarring in the Drosophila embryo.
Article in Nature cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis.Current biology : CB · 2026Article
- Supracellular actomyosin assemblies: master coordinators of development.Development (Cambridge, England) · 2025Review
- Automorphy as a self-organizing DPP-dependent process that translates patterns into mechanical programs duringScience advances · 2025Article
- A transient contractile seam promotes epithelial sealing and sequential assembly of body segments.Nature communications · 2025Article
- An actomyosin network organizes niche morphology and responds to feedback from recruited stem cells.Current biology : CB · 2024Article
- An actomyosin network organizes niche morphology and responds to feedback from recruited stem cells.bioRxiv : the preprint server for biology · 2024Article
- Lateral adherens junctions mediate a supracellular actomyosin cortex in drosophila trachea.iScience · 2023Article
- Zasp52 strengthens whole embryo tissue integrity through supracellular actomyosin networks.Development (Cambridge, England) · 2023Article
- JNK signaling and integrins cooperate to maintain cell adhesion during epithelial fusion inFrontiers in cell and developmental biology · 2023Article
- SCAR/WAVE complex recruitment to a supracellular actomyosin cable by myosin activators and a junctional Arf-GEF duringMolecular biology of the cell · 2022Article
- Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo.Development (Cambridge, England) · 2022Article
- Proximate larval epidermal cell layer generates forces for Pupal thorax closure in Drosophila.Genetics · 2022Article
- A Comparative Study of the Role of Formins inCells · 2022Article
- Leading-edge elongation by follower cell interruption in advancing epithelial cell sheets.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Septate junction proteins are required for cell shape changes, actomyosin reorganization and cell adhesion during dorsal closure inFrontiers in cell and developmental biology · 2022Article
- The Lateral Epidermis Actively Counteracts Pulling by the Amnioserosa During Dorsal Closure.Frontiers in cell and developmental biology · 2022Article
- Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues.Frontiers in cell and developmental biology · 2022Review
- Article
- Actin-based force generation and cell adhesion in tissue morphogenesis.Current biology : CB · 2021Review
- Hindbrain neuropore tissue geometry determines asymmetric cell-mediated closure dynamics in mouse embryos.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
The actin cable is a supracellular structure that embryonic epithelia produce to close gaps. However, the action of the cable remains debated. Here, we address the function of the cable using Drosophila dorsal closure, a paradigm to understand wound healing. First, we show that the actin cytoskeleton protein Zasp52 is specifically required for actin cable formation. Next, we used Zasp52 loss of function to dissect the mechanism of action of the cable. Surprisingly, closure dynamics are perfect in Zasp52 mutants: the cable is therefore dispensable for closure, even in the absence of the amnioserosa. Conversely, we observed that the cable protects cellular geometries from robust morphogenetic forces that otherwise interfere with closure: the absence of cable results in defects in epithelial organization that lead to morphogenetic scarring. We propose that the cable prevents morphogenetic scarring by stabilizing cellular interactions rather than by acting on closure dynamics.
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