Evidence map›Paper›PMID 27749744›Full record

ArticlePsychosomatic medicine

Early Adversity, Psychopathology, and Latent Class Profiles of Global Physical Health From Preschool Through Early Adolescence.

Diana J Whalen, Andy C Belden, Rebecca Tillman, Deanna M Barch, Joan L Luby

Abstract read
In one paragraph

Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Review
  3. The Impact of Early Life Adversity on Peripubertal Accelerated Epigenetic Aging and Psychopathology.Journal of the American Academy of Child and Adolescent Psychiatry · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Adolescents with Type 2 Diabetes: Overcoming Barriers to Effective Weight Management.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Preschool Depression: a Diagnostic Reality.Current psychiatry reports · 2019
    Review
  17. Article
  18. Review
  19. Depression and Anxiety in Preschoolers: A Review of the Past 7 Years.Child and adolescent psychiatric clinics of North America · 2017
    Review
  20. Update on the pathogenesis of atopic dermatitis.Anais brasileiros de dermatologia
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Diana J WhalenFrom the Department of Psychiatry (Whalen, Belden, Tillman, Barch, Luby), The Program in Neuroscience (Barch), Department of Psychology (Barch), and Department of Radiology (Barch), Washington University School of Medicine, St. Louis, Missouri.
Andy C Belden
Rebecca Tillman
Deanna M Barch
Joan L Luby

Funding

Validation of Preschool Depressive SyndromeR01MH064769 · NIMH · WASHINGTON UNIVERSITY · PI LUBY, JOAN L. · 2003 to 2012
$7.7M
Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
NIMH NIH HHS L30 MH108015NIMH NIH HHS R01 MH064769NIMH NIH HHS T32 MH100019
6 · The paper itself

Abstract

objectiveThe purpose of the present report was to describe the longitudinal trajectories of physical health beginning during preschool and continuing into early adolescence; explore whether these trajectories were predicted by psychosocial adversity, family income-to-needs ratio, and psychiatric disorders occurring during the preschool period; and determine whether psychiatric disorders mediated these relations.

methodsParticipants included 296 children participating in a longitudinal study of early-onset psychopathology spanning 10 years. Semistructured clinical interviews were conducted with caregivers to determine children's psychiatric diagnoses between ages 3 and 6 years. Caregivers also completed annual assessments of their child's physical health problems (ages 3-13) and reported on the family's income and indicators of psychosocial adversity.

resultsGrowth mixture modeling revealed 2 trajectories of physical health problems: a stable, low group (n = 199) and a high, increasing group (n = 57) indicating linear increases in physical health problems from ages 3 to 13. Preschool psychiatric diagnoses (Estimate [Est] = 0.05, p < .001), family income-to-needs ratio (Est = -0.01, p = .012), and psychosocial adversity (Est = 0.02, p = .015) predicted membership in the high, increasing trajectory of physical health problems. Early-onset psychopathology mediated relations between psychosocial adversity and physical health problems (αβ = 0.31, p = .050) and between income-to-needs ratio and physical health problems (αβ = -0.29, p < .021).

conclusionsThese findings indicate the importance of early indicators of risk: low income-to-needs ratios, high psychosocial adversity, and psychiatric disorders occurring during the preschool period for contributing to increasing physical health problems from preschool through early adolescence. Early-onset psychiatric disorders also mediated relations between psychosocial adversity, income-to-needs ratio, and physical health problems.

Indexed as

Health StatusSocial ClassAdolescentAdolescent DevelopmentChildChild AbuseChild DevelopmentChild, PreschoolFemaleHumansMaleMental Disorders

Identifiers

PMID27749744
PMCPMC5108573

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.