Evidence map›Paper›PMID 27749737›Full record

Observational studyMenopause (New York, N.Y.)2017

Bioavailable insulin-like growth factor-I as mediator of racial disparity in obesity-relevant breast and colorectal cancer risk among postmenopausal women.

Su Yon Jung, Wendy E Barrington, Dorothy S Lane, Chu Chen, Rowan Chlebowski, Giselle Corbie-Smith, Lifang Hou, Zuo-Feng Zhang, Min-So Paek, Carolyn J Crandall

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Menopause (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Su Yon Jung1Translational Sciences Section, Jonsson Comprehensive Cancer Center, School of Nursing, University of California, Los Angeles, Los Angeles, CA 2Psychosocial & Community Health, School of Nursing, University of Washington, Seattle, WA 3Department of Family, Population and Preventive Medicine, Stony Brook University School of Medicine, Stony Brook, NY 4Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 5Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 6Department of Medicine, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 7Department of Preventive Medicine & Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University Chicago, IL 8Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 9Department of Social Welfare, Konkuk University, Chungju, South Korea 10Division of General Internal Medicine, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
Wendy E Barrington
Dorothy S Lane
Chu Chen
Rowan Chlebowski
Giselle Corbie-Smith
Lifang Hou
Zuo-Feng Zhang
Min-So Paek
Carolyn J Crandall
University of California, Los Angeles · USFred Hutch Cancer Center · USKonkuk University · KRNorthwestern University · USStony Brook University · USThe Lundquist Institute · USUniversity of North Carolina at Chapel Hill · USUniversity of Washington · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Mentoring in community influences on CVD riskK24HL105493 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CORBIE, GISELLE · 2010 to 2019
$1.5M
NCI NIH HHS P30 CA060553NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS K24 HL105493NIA NIH HHS HHSN271201100004CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

objectiveBioavailable insulin-like growth factor-I (IGF-I) interacts with obesity and exogenous estrogen (E) in a racial disparity in obesity-related cancer risk, yet their interconnected pathways are not fully characterized. We investigated whether circulating bioavailable IGF-I acted as a mediator of the racial disparity in obesity-related cancers such as breast and colorectal (CR) cancers and how obesity and E use regulate this relationship.

methodsA total of 2,425 white and 164 African American (AA) postmenopausal women from the Women's Health Initiative Observational Study were followed from October 1, 1993 through August 29, 2014. To assess bioactive IGF-I as a mediator of race-cancer relationship, we used the Baron-Kenny method and quantitative estimation of the mediation effect.

resultsCompared with white women, AA women had higher IGF-I levels; their higher risk of CR cancer, after accounting for IGF-I, was no longer significant. IGF-I was associated with breast and CR cancers even after controlling for race. Among viscerally obese (waist/hip ratio >0.85) and overall nonobese women (body mass index <30), IGF-I was a strong mediator, reducing the racial disparity in both cancers by 30% and 60%, respectively. In E-only users and nonusers, IGF-I explained the racial disparity in CR cancer only modestly.

conclusionsBioavailable IGF-I is potentially important in racial disparities in obesity-related breast and CR cancer risk between postmenopausal AA and white women. Body fat distribution and E use may be part of the interconnected hormonal pathways related to racial difference in IGF-I levels and obesity-related cancer risk.

Indexed as

Black or African AmericanWhite PeopleAgedBiological AvailabilityBreast NeoplasmsColorectal NeoplasmsEstrogensFemaleHealth Status DisparitiesHumansInsulin-Like Growth Factor IMiddle AgedObesityPostmenopauseRisk FactorsEstrogensIGF1 protein, humanInsulin-Like Growth Factor I

Identifiers

PMID27749737
PMCPMC5323280
OpenAlexW2528362558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.