Evidence map›Paper›PMID 27749682›Full record

ArticlePsychosomatic medicine

Dimensions of Socioeconomic Status and Childhood Asthma Outcomes: Evidence for Distinct Behavioral and Biological Associations.

Edith Chen, Madeleine U Shalowitz, Rachel E Story, Katherine B Ehrlich, Cynthia S Levine, Robin Hayen, Adam K K Leigh, Gregory E Miller

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05390554 (Effect of Buteyko Breathing Technique on Asthma Severity Control Among School-Age Children), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05390554 nacompletednot on this map

Effect of Buteyko Breathing Technique on Asthma Severity Control Among School-Age Children

TypeinterventionalSponsorMansoura UniversityRan2019 to 2019Enrolled33ConditionsChildhood AsthmaArmsButeyko Breathing Technique
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Socioeconomic status, prefrontal cortical volume, and cardiometabolic risk in early adolescence.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025
    Article
  3. Article
  4. Sustained Effects From a School-Based Intervention Pilot Study for Children With Asthma and Anxiety.The Journal of school nursing : the official publication of the National Association of School Nurses · 2022
    Article
  5. Article
  6. Article
  7. Structural racism and its pathways to asthma and atopic dermatitis.The Journal of allergy and clinical immunology · 2021
    Review
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Observational
  14. Article
  15. Future Directions in the Study of Early-Life Stress and Physical and Emotional Health: Implications of the Neuroimmune Network Hypothesis.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Edith ChenFrom the Institute for Policy Research and Department of Psychology (Chen, Ehrlich, Levine, Hayen, Leigh, Miller), Northwestern University, Evanston, IL; Center for Clinical Research Informatics (Shalowitz), NorthShore University HealthSystem, and Department of Medicine (Story), NorthShore University HealthSystem, Evanston, IL.
Madeleine U Shalowitz
Rachel E Story
Katherine B Ehrlich
Cynthia S Levine
Robin Hayen
Adam K K Leigh
Gregory E Miller
NorthShore University HealthSystem · US

Funding

Multi-Level Understanding of Social Contributors to SES Disparities in AsthmaR01HL108723 · NHLBI · NORTHWESTERN UNIVERSITY · PI CHEN, EDITH · 2012 to 2016
$2.0M
Adolescent Social Relationships and Immune, Endocrine, and Metabolic ProcessesF32HD076563 · NICHD · NORTHWESTERN UNIVERSITY · PI EHRLICH, KATHERINE BABCOCK · 2013 to 2014
$99k
NHLBI NIH HHS R01 HL108723NICHD NIH HHS F32 HD076563
6 · The paper itself

Abstract

objectivesThe objective of this study was to investigate 2 key dimensions of socioeconomic status (SES)-prestige and resources-and their associations with immune, behavioral, and clinical outcomes in childhood asthma.

methodsChildren ages 9 to 17 years with a physician's diagnosis of asthma (N = 150), and one of their parents participated in this study. Children and parents completed interviews and questionnaires about SES (prestige = parent education; resources = family assets), environmental exposures, and clinical asthma measures. Spirometry was conducted to assess children's pulmonary function, and blood was collected to measure cytokine production in response to nonspecific stimulation, allergen-specific stimulation, and microbial stimulation.

resultsHigher scores on both dimensions of childhood SES were associated with better clinical outcomes in children (β's from |.18 to .27|, p values < .05). Higher prestige, but not resources, was associated with better home environment control behaviors and less exposure to smoke (β's from |.21 to .22|, p values < .05). Higher resources, but not prestige, was associated with more favorable immune regulation, as manifest in smaller peripheral blood mononuclear cell (PBMC) TH1 and TH2 cytokine responses (β's from -.18 to -.19; p values < .05), and smaller proinflammatory cytokine responses (β = -.19; p < .05) after ex vivo stimulation. Higher resources also were associated with more sensitivity to glucocorticoid inhibition of TH1 and TH2 cytokine production (β's from -.18 to -.22; p values < .05).

conclusionsThese results suggest that prestige and resources in childhood family environments have different implications for behavioral and immunological processes relevant to childhood asthma. They also suggest that childhood SES relates to multiple aspects of immunologic regulation of relevance to the pathophysiology of asthma.

Indexed as

AsthmaEducational StatusHealth BehaviorSocial ClassAdolescentChildFemaleHumansIncomeMale

Identifiers

PMID27749682
PMCPMC5096956
OpenAlexW2524917632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.