Observational studyMedicine2016
No associations exist between mean platelet volume or platelet distribution width and thyroid function in Chinese.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Thyroid hormones and platelet activation in COVID-19 patients.Journal of endocrinological investigation · 2023Article
- Assessing causal associations of hyperparathyroidism with blood counts and biochemical indicators: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Impact of Red Cell and Platelet Distribution Width in Patients of Medical Intensive Care Unit.Journal of laboratory physicians · 2021Article
- The different associations between platelet distribution width and hypertension subtypes in males and females.Bioscience reports · 2020Article
- Association between platelet distribution width and prognosis in patients with heart failure.PloS one · 2020Observational
- Gender impact on the correlations between Graves' hyperthyroidism and hyperuricemia in Chinese.Irish journal of medical science · 2019Article
- The relationship between red blood cell distribution width and metabolic syndrome in elderly Chinese: a cross-sectional study.Lipids in health and disease · 2019Article
- Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/ Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma.Endocrine, metabolic & immune disorders drug targets · 2019Article
- Gender- and Age-Specific Differences in the Association of Hyperuricemia and Hypertension: A Cross-Sectional Study.International journal of endocrinology · 2019Article
- Serum bilirubin is negatively associated with white blood cell count.Clinics (Sao Paulo, Brazil) · 2019Article
- Gender-Specific Differences on the Association of Hypertension with Subclinical Thyroid Dysfunction.International journal of endocrinology · 2019Article
- No associations exists between red blood cell distribution width and serum uric acid in both sexes.Medicine · 2018Article
- Relationship between mean platelet volume and metabolic syndrome in Chinese patients.Scientific reports · 2018Article
- The association between total bilirubin and serum triglyceride in both sexes in Chinese.Lipids in health and disease · 2018Article
- Infectious mononucleosis and hepatic function.Experimental and therapeutic medicine · 2018Article
- Platelet Distribution Width and Serum Albumin Levels for Discrimination of Thyroid Cancer From Benign Thyroid NodulesAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Mean Platelet Volume in Graves' disease: A Sign of Hypermetabolism Rather than Autoimmunity?Pakistan journal of medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mean platelet volume (MPV) and platelet distribution width (PDW) are morphometric indices of size distribution and variability of platelet. We aimed to explore the associations between MPV or PDW and thyroid function in a large Chinese cohort.This was a cross-sectional study with a recruitment of 13,622 self-reported healthy Chinese (8424 males, 5198 females). Clinical data of the participants comprised of anthropometric measurements, hepatic function, renal function, serum levels of lipid, glucose, C-reactive protein, erythrocyte sedimentation rate, platelet, MPV, PDW, and thyroid hormones. Database was sorted by sex, and the associations between MPV or PDW and thyroid function were analyzed by quartiles of MPV or PDW. Levels of MPV and PDW were compared in different thyroid function subgroups by 1-way analysis of variance and independent sample's t test. Receiver-operating characteristic (ROC) curve was adopted to determine diagnostic values of MPV and PDW for thyroid dysfunction. Crude and adjusted odds ratios of MPV and PDW for thyroid dysfunction with 95% confidence intervals were analyzed by binary logistic regression models.MPV, PDW, and thyroid stimulation hormone were significantly higher in females than in males. Females showed significantly higher incidence of hypothyroidism and hyperthyroidism than males. However, there were no significant differences of MPV and PDW among different thyroid function subgroups in both sexes, and no obvious correlations were revealed between MPV or PDW and thyroid function. From ROC analysis, we demonstrated no diagnostic values of MPV and PDW for thyroid dysfunction. From binary logistic regression models, no risks of different MPV and PDW quartiles were identified for thyroid dysfunction in both sexes.We could not show any association between MPV or PDW and thyroid function. Prospective studies with better defined risk groups should be performed in the future for further verification and validation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.