Evidence map›Paper›PMID 27748889›Full record

ArticleMolecular medicine reports2016

MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder.

Ziru Liu, Zhulin Yang, Song Jiang, Qiong Zou, Yuan Yuan, Jinghe Li, Daiqiang Li, Lufeng Liang, Meigui Chen, Senlin Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Comparative Outcomes of Adenosquamous Carcinoma of the Gallbladder: an Analysis of the National Cancer Database.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ziru LiuDepartment of Minimal Invasive Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Zhulin YangResearch Laboratory of Hepatobiliary Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Song JiangResearch Laboratory of Hepatobiliary Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Qiong ZouDepartment of Pathology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China.
Yuan YuanDepartment of Pathology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China.
Jinghe LiDepartment of Pathology, Basic School of Medicine, Changsha, Hunan 410078, P.R. China.
Daiqiang LiDepartment of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Lufeng LiangDepartment of Hepatobiliary and Pancreatic Surgery, Hunan Provincial People's Hospital, Changsha, Hunan 410007, P.R. China.
Meigui ChenDepartment of Pathology, Loudi Central Hospital, Loudi, Hunan 417011, P.R. China.
Senlin ChenDepartment of Pathology, Hunan Provincial Tumor Hospital, Changsha, Hunan 410013, P.R. China.
Central South University · CNSecond Xiangya Hospital of Central South University · CNHunan Provincial People's Hospital · CNLoudi Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinicopathological and biological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) of the gallbladder remain to be fully elucidated, due to the fact that it is a rare gallbladder cancer subtype. In the current study, the expression of minichromosome maintenance complex component 2 (MCM2) and HIV‑1 tat interactive protein 2 (TIP30) was measured in 46 cases of SC/ASC and 80 adenocarcinomas (AC) using immunohistochemistry. Positive MCM2 and negative TIP30 expression were significantly associated with large tumor size, high TNM stage, invasion, lymph node metastasis and lack of surgical curability in SC/ASC and AC. Positive MCM2 and negative TIP30 expression were significantly associated with poor differentiation in AC, whereas only MCM2 was correlated with differentiation in SC/ASC. Univariate Kaplan‑Meier analysis demonstrated that positive MCM2 and negative TIP30 expression, the degree of differentiation, tumor size, TNM stage, invasion, lymph node metastasis and surgical curability were significantly associated with post‑operative survival in patients with SC/ASC and AC. Multivariate Cox regression analysis demonstrated that positive MCM2 and negative TIP30 expression, the degree of differentiation, tumor size, TNM stage, invasion, lymph node metastasis and lack of surgical curability were also independent predictors of poor prognosis in patients with SC/ASC and AC. These data suggest that positive MCM2 and negative TIP30 expression are closely correlated with the clinical, pathological and biological parameters, in addition to poor prognosis in patients with gallbladder cancer.

Indexed as

AcetyltransferasesAdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, AdenosquamousCarcinoma, Squamous CellFemaleGallbladder NeoplasmsGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedAcetyltransferasesBiomarkers, TumorHTATIP2 protein, humanMCM2 protein, humanMinichromosome Maintenance Complex Component 2Transcription Factors

Identifiers

PMID27748889
PMCPMC5102005
OpenAlexW2531334226

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.