ArticleNature communications2016
Stereotypic wheel running decreases cortical activity in mice.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 74 citations in OpenAlex.
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- Noradrenergic tone is not required for neuronal activity-induced rebound sleep in zebrafish.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue.Nature communications · 2023Article
- Sleep-like changes in neural processing emerge during sleep deprivation in early auditory cortex.Current biology : CB · 2023Article
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- Detection of neuronal OFF periods as low amplitude neural activity segments.BMC neuroscience · 2023Article
- Neuronal-spiking-based closed-loop stimulation during cortical ON- and OFF-states in freely moving mice.Journal of sleep research · 2022Article
- Reduced neural activity but improved coding in rodent higher-order visual cortex during locomotion.Nature communications · 2022Article
- Input rate encoding and gain control in dendrites of neocortical pyramidal neurons.Cell reports · 2022Article
- The hypothalamic link between arousal and sleep homeostasis in mice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The relationship between fasting-induced torpor, sleep, and wakefulness in laboratory mice.Sleep · 2021Article
- Diazepam effects on local cortical neural activity during sleep in mice.Biochemical pharmacology · 2021Article
- The overfitted brain: Dreams evolved to assist generalization.Patterns (New York, N.Y.) · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Prolonged wakefulness is thought to gradually increase 'sleep need' and influence subsequent sleep duration and intensity, but the role of specific waking behaviours remains unclear. Here we report the effect of voluntary wheel running during wakefulness on neuronal activity in the motor and somatosensory cortex in mice. We find that stereotypic wheel running is associated with a substantial reduction in firing rates among a large subpopulation of cortical neurons, especially at high speeds. Wheel running also has longer-term effects on spiking activity across periods of wakefulness. Specifically, cortical firing rates are significantly higher towards the end of a spontaneous prolonged waking period. However, this increase is abolished when wakefulness is dominated by running wheel activity. These findings indicate that wake-related changes in firing rates are determined not only by wake duration, but also by specific waking behaviours.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.