ArticleScientific reports2016
Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Dietary intake of vitamins B1, B2, B3, and B6, and the risk of gastric cancer: pooled analyses within the Stomach cancer Pooling (Stop) project.European journal of nutrition · 2026Article
- γH2AX and p53 Immunohistochemistry predict the incidence risk of esophageal squamous precancerous lesions.BMC medicine · 2026Article
- One-carbon metabolism biomarkers and upper gastrointestinal cancer in the Golestan Cohort Study.International journal of cancer · 2024Article
- Serum ghrelin and esophageal and gastric cancer in two cohorts in China.International journal of cancer · 2020Article
- Prospective cohort studies of dietary vitamin B6 intake and risk of cause-specific mortality.Clinical nutrition (Edinburgh, Scotland) · 2019Article
- What have we learned from Linxian esophageal cancer etiological studies?Thoracic cancer · 2019Review
- Nut consumption and the risk of oesophageal squamous cell carcinoma in the Golestan Cohort Study.British journal of cancer · 2018Article
- Associations between dietary folate intake and risks of esophageal, gastric and pancreatic cancers: an overall and dose-response meta-analysis.Oncotarget · 2017Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
B vitamins play an essential role in DNA synthesis and methylation, and may protect against oesophageal and gastric cancers. In this case-cohort study, subjects were enrolled from the General Population Nutrition Intervention Trial in Linxian, China. Subjects included 498 oesophageal squamous cell carcinomas (OSCCs), 255 gastric cardia adenocarcinomas (GCAs), and an age- and sex-matched sub-cohort of 947 individuals. Baseline serum riboflavin, pyridoxal phosphate (PLP), folate, vitamin B12, and flavin mononucleotide (FMN) were measured for all subjects. We estimated the associations with Cox proportional hazard models, with adjustment for potential confounders. Compared to those in the lowest quartile of serum riboflavin, those in the highest had a 44% lower risk of OSCC (HR: 0.56, 95% CI: 0.41 to 0.75). Serum vitamin B12 as a continuous variable was observed to be significantly inversely associated with OSCC (HR: 0.95, 95% CI: 0.89 to 1.01, P for score test = 0.041). Higher serum FMN levels were significantly associated with increased risk of OSCC (HR: 1.08, 95% CI: 1.01 to 1.16) and GCA (HR: 1.09, 95% CI: 1.00 to 1.20). Our study prompted that B vitamins have the potential role as chemopreventive agents for upper gastrointestinal cancers.
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