Evidence map›Paper›PMID 27748373›Full record

ArticleLeukemia2017

Impact of graft-versus-host disease on outcomes after unrelated cord blood transplantation.

J Kanda, Y Morishima, S Terakura, A Wake, N Uchida, S Takahashi, Y Ono, Y Onishi, H Kanamori, N Aotsuka and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Leukemia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

J KandaDivision of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
Y MorishimaDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
S TerakuraDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
A WakeDepartment of Hematology, Toranomon Hospital, Tokyo, Japan.
N UchidaDepartment of Hematology, Toranomon Hospital, Tokyo, Japan.
S TakahashiDepartment of Molecular Therapy, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Y OnoDepartment of Internal Medicine, Kitakyushu Municipal Medical Center, Kitakyushu, Japan.
Y OnishiDepartment of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan.
H KanamoriDepartment of Hematology, Kanagawa Cancer Center, Kanagawa, Japan.
N AotsukaDivision of Hematology-Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan.
Y OzawaDepartment of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
H OgawaDivision of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
T SakuraLeukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan.
K OhashiHematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
T IchinoheDepartment of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
K KatoDepartment of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
Y AtsutaJapanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.
T TeshimaDepartment of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
M MurataDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of graft-versus-host disease (GVHD) on transplant outcomes after unrelated cord blood transplantation (UCBT) has not been fully elucidated. We analyzed the impact of acute and chronic GVHD on outcomes in adult patients with acute leukemia or myelodysplastic syndrome who underwent their first UCBT (n=2558). The effect of GVHD on outcomes was analyzed after adjusting for other significant variables. The occurrence of GVHD was treated as a time-dependent covariate. The occurrence of grade 1-2 or 3-4 acute GVHD was significantly associated with a lower relapse rate. Grade 3-4 acute GVHD was associated with a higher risk of non-relapse and overall mortality than no acute GVHD, whereas grade 1-2 acute GVHD was associated with a lower risk of non-relapse and overall mortality than no acute GVHD. Limited or extensive chronic GVHD was significantly associated with a lower relapse rate. Limited chronic GVHD was associated with a lower overall and non-relapse mortality than no chronic GVHD. In conclusion, mild acute or chronic GVHD was associated not only with a low risk of relapse but also with a low risk of non-relapse mortality, and provides a survival benefit in UCBT.

Indexed as

AdolescentAdultAgedAged, 80 and overCause of DeathCord Blood Stem Cell TransplantationFemaleGraft vs Host DiseaseHumansMaleMiddle AgedPatient Outcome AssessmentRecurrenceSeverity of Illness IndexSurvival AnalysisTransplantation Conditioning

Identifiers

PMID27748373

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.