Evidence map›Paper›PMID 27748361›Full record

ArticleScientific reports2016

Fabricating customized hydrogel contact lens.

Andre Childs, Hao Li, Daniella M Lewittes, Biqin Dong, Wenzhong Liu, Xiao Shu, Cheng Sun, Hao F Zhang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 78 citations in OpenAlex.

  1. Biogenic silver nanoparticles from chamomile incorporated in hydrogels for high transparent non-infectiveness contact lenses.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
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  17. Microfluidic Contact Lenses.Small (Weinheim an der Bergstrasse, Germany) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Andre ChildsDepartment of Physics and Astronomy, University of Texas at San Antonio, San Antonio, TX, 78249, USA.
Hao LiDepartment of Biomedical Engineering, Northwestern University, Evanston IL 60208, USA.
Daniella M LewittesDepartment of Biomedical Engineering, Northwestern University, Evanston IL 60208, USA.
Biqin DongDepartment of Biomedical Engineering, Northwestern University, Evanston IL 60208, USA.
Wenzhong LiuDepartment of Biomedical Engineering, Northwestern University, Evanston IL 60208, USA.
Xiao ShuDepartment of Biomedical Engineering, Northwestern University, Evanston IL 60208, USA.
Cheng SunDepartment of Mechanical Engineering, Northwestern University, Evanston IL 60208, USA.
Hao F ZhangDepartment of Biomedical Engineering, Northwestern University, Evanston IL 60208, USA.
Northwestern University · USThe University of Texas at San Antonio · US

Funding

Novel Antiangiogenic Peptides for Treatment of Exudative AMDR24EY022883 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SHEIBANI, NADER · 2013 to 2017
$6.2M
Multimodal Retinal Functional Imaging for Diabetic RetinopathyR01EY019951 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FAWZI, AMANI A, JIAO, SHULIANG · 2011 to 2015
$3.0M
Functional Retinal Imaging to Monitor Pharmaco-Therapies in Diabetic RetinopathyDP3DK108248 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FAWZI, AMANI A, ZHANG, HAO F · 2015 to 2015
$1.9M
Howard Hughes Medical InstituteNEI NIH HHS R01 EY019951NEI NIH HHS R24 EY022883NIDDK NIH HHS DP3 DK108248
6 · The paper itself

Abstract

Contact lenses are increasingly used in laboratories for in vivo animal retinal imaging and pre-clinical studies. The lens shapes often need modification to optimally fit corneas of individual test subjects. However, the choices from commercially available contact lenses are rather limited. Here, we report a flexible method to fabricate customized hydrogel contact lenses. We showed that the fabricated hydrogel is highly transparent, with refractive indices ranging from 1.42 to 1.45 in the spectra range from 400 nm to 800 nm. The Young's modulus (1.47 MPa) and hydrophobicity (with a sessile drop contact angle of 40.5°) have also been characterized experimentally. Retinal imaging using optical coherence tomography in rats wearing our customized contact lenses has the quality comparable to the control case without the contact lens. Our method could significantly reduce the cost and the lead time for fabricating soft contact lenses with customized shapes, and benefit the laboratorial-used contact lenses in pre-clinical studies.

Indexed as

Contact Lenses, HydrophilicElastic ModulusAnimalsBiocompatible MaterialsCorneaEquipment DesignHydrogelsHydrophobic and Hydrophilic InteractionsMaterials TestingPressureRatsRats, Long-EvansRefractometryRetinaStress, MechanicalTomography, Optical CoherenceBiocompatible MaterialsHydrogelsWater

Identifiers

PMID27748361
PMCPMC5066254
OpenAlexW2532893565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.