ArticleSleep2016
Different Simultaneous Sleep States in the Hippocampus and Neocortex.
Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- A-phase Occurrence During Sleep in the Deep Brain Recordings: Multiscale-Entropy and Multiscale-DFA Analysis.Brain topography · 2026Article
- Respiratory pauses highlight sleep architecture in mice.Nature communications · 2026Article
- Global and Regional Vigilance: Are There Two Types of Local Sleep?Brain and behavior · 2026Review
- Local sleep in songbirds: different simultaneous sleep states across the avian pallium.Journal of sleep research · 2025Article
- CB-1 receptor agonist drastically changes oscillatory activity, defining active sleep.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A continuous approach to explain insomnia and subjective-objective sleep discrepancy.Communications biology · 2025Article
- Functional connectivity drifts during sleep as a marker of fluctuations in the level of consciousness.Neuroscience of consciousness · 2025Article
- A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior.Nature neuroscience · 2024Article
- Adaptive modeling and inference of higher-order coordination in neuronal assemblies: A dynamic greedy estimation approach.PLoS computational biology · 2024Article
- Somnotate: A probabilistic sleep stage classifier for studying vigilance state transitions.PLoS computational biology · 2024Article
- Adaptive modeling and inference of higher-order coordination in neuronal assemblies: a dynamic greedy estimation approach.bioRxiv : the preprint server for biology · 2023Article
- Review
- A non-oscillatory, millisecond-scale embedding of brain state provides insight into behavior.bioRxiv : the preprint server for biology · 2023Article
- Regional variability in intracerebral properties of NREM to REM sleep transitions in humans.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Recurrent Hippocampo-neocortical sleep-state divergence in humans.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The why and how of sleep-dependent synaptic down-selection.Seminars in cell & developmental biology · 2022Article
- Article
- What Is REM Sleep?Current biology : CB · 2020Review
- Oscillating circuitries in the sleeping brain.Nature reviews. Neuroscience · 2019Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
STUDY
objectivesInvestigators assign sleep-waking states using brain activity collected from a single site, with the assumption that states occur at the same time throughout the brain. We sought to determine if sleep-waking states differ between two separate structures: the hippocampus and neocortex.
methodsWe measured electrical signals (electroencephalograms and electromyograms) during sleep from the hippocampus and neocortex of five freely behaving adult male rats. We assigned sleep-waking states in 10-sec epochs based on standard scoring criteria across a 4-h recording, then analyzed and compared states and signals from simultaneous epochs between sites.
resultsWe found that the total amount of each state, assigned independently using the hippocampal and neocortical signals, was similar between the hippocampus and neocortex. However, states at simultaneous epochs were different as often as they were the same (P = 0.82). Furthermore, we found that the progression of states often flowed through asynchronous state-pairs led by the hippocampus. For example, the hippocampus progressed from transition-to-rapid eye movement sleep to rapid eye movement sleep before the neocortex more often than in synchrony with the neocortex (38.7 ± 16.2% versus 15.8 ± 5.6% mean ± standard error of the mean).
conclusionsWe demonstrate that hippocampal and neocortical sleep-waking states often differ in the same epoch. Consequently, electrode location affects estimates of sleep architecture, state transition timing, and perhaps even percentage of time in sleep states. Therefore, under normal conditions, models assuming brain state homogeneity should not be applied to the sleeping or waking brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.