Evidence map›Paper›PMID 27748235›Full record

Trial reportJournal of developmental origins of health and disease2017

Effect of maternal zinc supplementation on the cardiometabolic profile of Peruvian children: results from a randomized clinical trial.

M L Mispireta, L E Caulfield, N Zavaleta, M Merialdi, D L Putnick, M H Bornstein, J A DiPietro

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of developmental origins of health and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Zinc supplementation for improving pregnancy and infant outcome.The Cochrane database of systematic reviews · 2021
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

M L Mispireta1Kasiska School of Health Professions,Idaho State University,Pocatello,ID,USA.
L E Caulfield2Department of International Health,Center for Human Nutrition,Johns Hopkins Bloomberg School of Public Health,Baltimore,MD,USA.
N Zavaleta4Instituto de Investigación Nutricional,Lima,Peru.
M Merialdi5Global Health Division,Becton Dickinson, Franklin Lakes,NJ,USA.
D L Putnick6Eunice Kennedy ShriverNational Institute of Child Health and Human Development,National Institutes of Health,Bethesda,MD,USA.
M H Bornstein6Eunice Kennedy ShriverNational Institute of Child Health and Human Development,National Institutes of Health,Bethesda,MD,USA.
J A DiPietro3Department of Population, Family and Reproductive Health,Johns Hopkins Bloomberg School of Public Health,Baltimore,MD,USA.
Johns Hopkins University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USBecton Dickinson (United States) · USInstituto de Investigación Nutricional · PE

Funding

Child and Family Development across the First Two+ Decades of LifeZIAHD001119 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BORNSTEIN, MARC H · 2009 to 2019
$20.9M
Supplemental zinc &fetal development: 4-year follow-upR01HD042675 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CAULFIELD, LAURA E · 2002 to 2005
$947k
Intramural NIH HHS Z99 HD999999NICHD NIH HHS R01 HD042675
6 · The paper itself

Abstract

Zinc is an essential micronutrient for the development of the fetal renal, cardiovascular and metabolic systems; however, there is limited evidence of its effects on the postnatal cardiometabolic function. In this study, we evaluated the effect of maternal zinc supplementation during pregnancy on the cardiometabolic profile of the offspring in childhood. A total of 242 pregnant women were randomly assigned to receive a daily supplement containing iron+folic acid with or without zinc. A follow-up study was conducted when children of participating mothers were 4.5 years of age to evaluate their cardiometabolic profile, including anthropometric measures of body size and composition, blood pressure, lipid profile and insulin resistance. No difference in measures of child cardiometabolic risk depending on whether mothers received supplemental zinc during pregnancy. Our results do not support the hypothesis that maternal zinc supplementation reduces the risk of offspring cardiometabolic disease.

Indexed as

Dietary SupplementsMaternal Nutritional Physiological PhenomenaAdultCardiovascular DiseasesChildDouble-Blind MethodFemaleGestational AgeHumansInfant, NewbornMaleMetabolic SyndromePeruPregnancyYoung AdultZincZinccardiovascularmetaboliczinc

Identifiers

PMID27748235
PMCPMC5822716
OpenAlexW2537728133

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.