The small-molecule 3G11 inhibits HIV-1 reverse transcription.
Silvana Opp, Thomas Fricke, Caitlin Shepard, Dmytro Kovalskyy, Akash Bhattacharya, Frank Herkules, Dmitri N Ivanov, Baek Kim, Jose Valle-Casuso, Felipe Diaz-Griffero
Article in Chemical biology & drug design, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 7 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors at 3 institutions in 1 country.
Silvana OppDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Thomas FrickeDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Caitlin ShepardDepartment of Pediatrics, Emory University, Atlanta, GA, USA.
Dmytro KovalskyyDepartment of Biochemistry, University of Texas Health Science Center, San Antonio, TX, USA.
Akash BhattacharyaDepartment of Biochemistry, University of Texas Health Science Center, San Antonio, TX, USA.ORCID 0000-0001-8748-9969
Frank HerkulesDepartment of Biochemistry, University of Texas Health Science Center, San Antonio, TX, USA.
Dmitri N IvanovDepartment of Biochemistry, University of Texas Health Science Center, San Antonio, TX, USA.
Baek KimDepartment of Pediatrics, Emory University, Atlanta, GA, USA.
Jose Valle-CasusoDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Felipe Diaz-GrifferoDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Albert Einstein College of Medicine · USThe University of Texas Health Science Center at San Antonio · USEmory University · US
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Role of Cellular Factors in Retroviral Uncoating and Synthesis of Viral DNAR01AI087390 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DIAZ-GRIFFERO, FELIPE · 2010 to 2024
$6.8M
Retroviral capsid recognition by TRIM5alpha restriction factorsR01AI104476 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI IVANOV, DMITRI N · 2014 to 2018
$1.8M
Defining the microtubule motors which drive the uncoating and trafficking of HIVR01AI120956 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI CAMPBELL, EDWARD M, DIAZ-GRIFFERO, FELIPE · 2015 to 2019
$1.6M
Regulation of SAMHD1 antiviral activityR01GM123540 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DIAZ-GRIFFERO, FELIPE · 2016 to 2018
$1.4M
Role of the B-box-v-1 Restriction by TRIM5alpha proteinsR00MH086162 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI DIAZ-GRIFFERO, FELIPE · 2010 to 2011
$496k
Role of TNPO3 in HIV-1 ReplicationR21AI102824 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DIAZ-GRIFFERO, FELIPE · 2013 to 2014
$444k
Regulation of SAMHD1 antiviral activityR56AI108432 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DIAZ-GRIFFERO, FELIPE · 2014 to 2014
$431k
Role of the B-box-2 Domain in HIV-1 Restriction by TRIM5alpha proteinsK99MH086162 · NIMH · DANA-FARBER CANCER INST · PI DIAZ-GRIFFERO, FELIPE · 2009 to 2009
The small-molecule 6-(tert-butyl)-4-phenyl-4-(trifluoromethyl)-1H,3H-1,3,5-triazin-2-one (3G11) inhibits HIV-1 replication in the human T cell line MT-2. Here, we showed that 3G11 specifically and potently blocks HIV-1 infection. By contrast, 3G11 did not block other retroviruses such as HIV-2, simian immunodeficiency virus (SIV
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The small-molecule 3G11 inhibits HIV-1 reverse transcription. · full record | OpenQuestion