Evidence map›Paper›PMID 27747846›Full record

ReviewSports medicine - open2015

Human tendon adaptation in response to mechanical loading: a systematic review and meta-analysis of exercise intervention studies on healthy adults.

Sebastian Bohm, Falk Mersmann, Adamantios Arampatzis

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sports medicine - open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07658300 (Transient Neuromuscular and Muscle-Tendon Adaptations Following Strength vs Endurance-Only Training in Competitive-Level Cyclists), which is not on this map. Cited by 196 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07658300 nacompletednot on this mapstarted 2023, after this paper: background citation

Transient Neuromuscular and Muscle-Tendon Adaptations Following Strength vs Endurance-Only Training in Competitive-Level Cyclists

TypeinterventionalSponsorLithuanian Sports UniversityRan2023 to 2024Enrolled24ConditionsHealthy Adult, Cyclists, AthletesArmsStrength training, Endurance training
3 · Its place in the literature

Who cites it

196 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  19. The Effects of Eccentric Contraction Execution Time on the Properties of the Patellar Tendon.International journal of environmental research and public health · 2022
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136 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sebastian BohmDepartment of Training and Movement Sciences, Humboldt-Universität zu Berlin, Philippstr. 13, Haus 11, 10115, Berlin, Germany.
Falk MersmannDepartment of Training and Movement Sciences, Humboldt-Universität zu Berlin, Philippstr. 13, Haus 11, 10115, Berlin, Germany.
Adamantios ArampatzisDepartment of Training and Movement Sciences, Humboldt-Universität zu Berlin, Philippstr. 13, Haus 11, 10115, Berlin, Germany. a.arampatzis@hu-berlin.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe present article systematically reviews recent literature on the in vivo adaptation of asymptomatic human tendons following increased chronic mechanical loading, and meta-analyzes the loading conditions, intervention outcomes, as well as methodological aspects.

methodsThe search was performed in the databases PubMed, Web of Knowledge, and Scopus as well as in the reference lists of the eligible articles. A study was included if it conducted (a) a longitudinal exercise intervention (≥8 weeks) on (b) healthy humans (18 to 50 years), (c) investigating the effects on mechanical (i.e., stiffness), material (i.e., Young's modulus) and/or morphological properties (i.e., cross-sectional area (CSA)) of tendons in vivo, and was reported (d) in English language. Weighted average effect sizes (SMD, random-effects) and heterogeneity (Q and I

resultsThe review process yielded 27 studies with 37 separate interventions on either the Achilles or patellar tendon (264 participants). SMD was 0.70 (confidence interval: 0.51, 0.88) for tendon stiffness (N=37), 0.69 (0.36, 1.03) for Young's modulus (N=17), and 0.24 (0.07, 0.42) for CSA (N=33), with significant overall intervention effects (p<0.05). The heterogeneity analysis (stiffness: I

conclusionsThe present meta-analysis provides elaborate statistical evidence that tendons are highly responsive to diverse loading regimens. However, the data strongly suggests that loading magnitude in particular plays a key role for tendon adaptation in contrast to muscle contraction type. Furthermore, intervention-induced changes in tendon stiffness seem to be more attributed to adaptations of the material rather than morphological properties.

Identifiers

PMID27747846
PMCPMC4532714

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.