ArticleSports medicine - open2015
A tutorial on oxidative stress and redox signaling with application to exercise and sedentariness.
Article in Sports medicine - open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Sex-Specific Relationships of Physical Activity and Sedentary Behaviour with Oxidative Stress and Inflammatory Markers in Young Adults.International journal of environmental research and public health · 2023Article
- Article
- Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate.Redox report : communications in free radical research · 2018Article
- Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation.Photochemistry and photobiology · 2018Review
- Markers and Biomarkers of Endothelium: When Something Is Rotten in the State.Oxidative medicine and cellular longevity · 2017Review
- Effects of acute physical exercise on oxidative stress and inflammatory status in young, sedentary obese subjects.PloS one · 2017Article
- Redox Mechanism of Reactive Oxygen Species in Exercise.Frontiers in physiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress has been shown to play a role in the etiology of several chronic diseases, including cardiovascular disease, diabetes mellitus, and cancer. Free radicals and, most prominently, the superoxide radical, result from oxidative metabolism and several enzyme-catalyzed reactions, and endogenous cellular antioxidants dismutate many reactive oxygen species (ROS). Under certain conditions, ROS production can outpace dismutation (e.g., long-term sedentariness and positive energy balance) and the result is oxidative stress, with proteins, lipids, and DNA the most common targets of radicals. However, the molecules that contribute to oxidative stress also appear to participate in vital cell signaling activity that supports health and stimulates favorable adaptations to exercise training, such that inhibiting ROS formation prevents common adaptations to training. Furthermore, researchers have recently suggested that some proteins are not as readily formed when the redox state of the cell is insufficiently oxidative. Exercise training appears to optimize the redox environment by dramatically enhancing the capacity of the cell to neutralize ROS while regularly creating oxidative environments in which membrane and secretory proteins can be synthesized. The role that exercise plays in enhancing management of ROS likely explains many of the associated health benefits.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.