ArticlePediatric nephrology (Berlin, Germany)2017
Non-invasive imaging cannot replace formal angiography in the diagnosis of renovascular hypertension.
Article in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 68 citations in OpenAlex.
- Mid-to-long term outcomes following renal artery angioplasty in children and young adults with renal artery stenosis: a retrospective review.Pediatric nephrology (Berlin, Germany) · 2025Article
- Pediatric Renovascular Hypertension: Diagnosis and Management.Seminars in interventional radiology · 2025Review
- Secondary Hypertension in Children-Identifying and Investigating at Risk Children.Current hypertension reports · 2025Review
- Imaging Diagnosis of Major Kidney and Urinary Tract Disorders in Children.Medicina (Kaunas, Lithuania) · 2025Review
- Renal Artery Stenosis and Mid-Aortic Syndrome in Children-A Review.Journal of clinical medicine · 2024Review
- Pediatric Renovascular Hypertension: A Pediatric Interventional Radiologist's Perspective.The Indian journal of radiology & imaging · 2023Review
- Multimodal imaging approach in hyponatremic hypertensive syndrome. A rare case of pediatric unilateral hypoplasia of the main renal artery combined itself with stenosis and review of literature.Radiology case reports · 2023Article
- Case Report: Renal artery stenosis in children: ultrasound as a decisive diagnostic and therapy-accompanying technique!Frontiers in pediatrics · 2023Article
- Presentation, treatment, and outcome of renovascular hypertension below 2 years of age.European journal of pediatrics · 2022Article
- Validation of computed tomography angiography as a complementary test in the assessment of renal artery stenosis: a comparison with digital subtraction angiography.Pediatric radiology · 2021Article
- Renovascular hypertension in pediatric patients: update on diagnosis and management.Pediatric nephrology (Berlin, Germany) · 2021Review
- Timing of procedural interventions in childhood renovascular hypertension.Pediatric nephrology (Berlin, Germany) · 2021Article
- Diagnostic sensitivity and specificity of CT angiography for renal artery stenosis in children.Pediatric radiology · 2021Article
- Renovascular hypertension in children.CVIR endovascular · 2021Review
- Renal artery assessment with non-enhanced MR angiography versus digital subtraction angiography: comparison between 1.5 and 3.0 T.European radiology · 2020Article
- The Value of Contrast-Enhanced Ultrasound versus Doppler Ultrasound in Grading Renal Artery Stenosis.BioMed research international · 2020Article
- Imaging studies in pediatric fibromuscular dysplasia (FMD): a single-center experience.Pediatric nephrology (Berlin, Germany) · 2018Article
- Difference between renal and splenic resistive index as a novel criterion in Doppler evaluation of renal artery stenosis.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Recommendations for ultrasonographic assessment of renal arteries.Journal of ultrasonography · 2018Article
- Ultrasound imaging of renin-mediated hypertension.Pediatric radiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesRenovascular disease (RVD) is found in about 10 % of secondary childhood hypertension. Digital subtraction angiography (DSA) is the gold standard to diagnose RVD. Non-invasive imaging methods like Doppler ultrasound (US), magnetic resonance angiography (MRA), and computed tomography angiography (CTA) are increasingly used. Our aim was to evaluate the role and accuracy of US, MRA, and CTA compared to DSA in diagnosing RVD in children. PATIENTS AND
methodsA retrospective review of 127 children with suspected renovascular hypertension was performed in children referred to Great Ormond Street Hospital between 2006 and 2014 due to clinical suspicion of renovascular hypertension and/or findings on US and/or MRA or CTA.
resultsNinety-nine of 127 children (78 %) were diagnosed with renovascular disease and 80 were treated with percutaneous transluminal angioplasty during the same procedure. The median age at presentation was 5.6 (range, 2.5-10.6) years. Thirty-six children had unilateral renal artery stenosis in major extraparenchymal vessels, 47 bilateral stenosis and 16 intrarenal small vessel disease. US had a sensitivity of 63 % and specificity of 95 %. MRA and CTA were performed in 39 and 34 children, respectively. CTA sensitivity was slightly higher than that of MRA, 88 vs. 80 %, and specificity 81 vs. 63 %.
conclusionsThe sensitivity of MRA and CTA is still too low to reliably rule out renovascular disease in children with a strong suspicion of this diagnosis. DSA remains the gold standard to diagnose renovascular hypertension and is recommended when clinical and laboratory criteria are highly suggestive of renovascular disease even with normal radiological investigations from non-invasive methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.