ArticleJournal of neurology2017
Exercise effects in Huntington disease.
Article in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Cognition-oriented treatments and physical exercise on cognitive function in Huntington's disease: a systematic review.Journal of neurology · 2023Pooled it
- Pooled it
- A Review of the Clinical Evidence for Complementary and Alternative Medicine in Huntington's Disease.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Pooled it
- Therapeutic Use of Music, Dance, and Rhythmic Auditory Cueing for Patients with Huntington's Disease: A Systematic Review.Journal of Huntington's disease · 2019Pooled it
- A moderate-intensity exercise program during inpatient rehabilitation for middle stage Huntington's disease: A randomized controlled trial.Journal of Huntington's disease · 2026Trial
- The Impact of Neurotoxin Proteins Trafficked by Primary Cilia and Extracellular Vesicles in Neurodegenerative Diseases.Biology · 2025Review
- Brain-Periphery Interactions in Huntington's Disease: Mediators and Lifestyle Interventions.International journal of molecular sciences · 2024Review
- Symptomatic treatment options for Huntington's disease (guidelines of the German Neurological Society).Neurological research and practice · 2023Article
- Effects of Exercise on Skeletal Muscle Pathophysiology in Huntington's Disease.Journal of functional morphology and kinesiology · 2022Review
- The protective role of exercise against age-related neurodegeneration.Ageing research reviews · 2022Review
- Clinical Decision Trees to Guide Physical Therapy Management of Persons with Huntington's Disease.Journal of Huntington's disease · 2022Review
- Cognitive Dysfunction in Repeat Expansion Diseases: A Review.Frontiers in aging neuroscience · 2022Review
- State-of-the-art pharmacological approaches to reduce chorea in Huntington's disease.Expert opinion on pharmacotherapy · 2021Article
- Moderate Intensity Exercise in Pre-manifest Huntington's Disease: Results of a 6 months Trial.SVOA neurology · 2021Article
- Approach to Posture and Gait in Huntington's Disease.Frontiers in bioengineering and biotechnology · 2021Review
- What and How Can Physical Activity Prevention Function on Parkinson's Disease?Oxidative medicine and cellular longevity · 2020Review
- Exercise Interventions in Huntington's Disease: An Individual Patient Data Meta-Analysis.Movement disorders clinical practice · 2019Article
- Exercise as a prescription for patients with various diseases.Journal of sport and health science · 2019Review
- Satellite cell content in Huntington's disease patients in response to endurance training.Orphanet journal of rare diseases · 2019Article
- Exercise in Huntington's Disease: Current State and Clinical Significance.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Huntington disease (HD) is a relentlessly progressive neurodegenerative disorder with symptoms across a wide range of neurological domains, including cognitive and motor dysfunction. There is still no causative treatment for HD but environmental factors such as passive lifestyle may modulate disease onset and progression. In humans, multidisciplinary rehabilitation has a positive impact on cognitive functions. However, a specific role for exercise as a component of an environmental enrichment effect has been difficult to demonstrate. We aimed at investigating whether endurance training (ET) stabilizes the progression of motor and cognitive dysfunction and ameliorates cardiovascular function in HD patients. Twelve male HD patients (mean ± SD, 54.8 ± 7.1 years) and twelve male controls (49.1 ± 6.8 years) completed 26 weeks of endurance training. Before and after the training intervention, clinical assessments, exercise physiological tests, and a body composition measurement were conducted and a muscle biopsy was taken from M. vastus lateralis. To examine the natural course of the disease, HD patients were additionally assessed 6 months prior to ET. During the ET period, there was a motor deficit stabilization as indicated by the Unified Huntington's Disease Rating Scale motor section score in HD patients (baseline: 18.6 ± 9.2, pre-training: 26.0 ± 13.7, post-training: 26.8 ± 16.4). Peak oxygen uptake ([Formula: see text]) significantly increased in HD patients (∆[Formula: see text] = +0.33 ± 0.28 l) and controls (∆[Formula: see text] = +0.29 ± 0.41 l). No adverse effects of the training intervention were reported. Our results confirm that HD patients are amenable to a specific exercise-induced therapeutic strategy indicated by an increased cardiovascular function and a stabilization of motor function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.