ArticleJACC. Basic to translational science2016
Neuronal Na
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Article in JACC. Basic to translational science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
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- Vascular Endothelial Barrier Protection Prevents Atrial Fibrillation by Preserving Cardiac Nanostructure.JACC. Clinical electrophysiology · 2023Article
- NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling.The Journal of clinical investigation · 2023Article
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- Ventricular voltage-gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation.Clinical and translational medicine · 2021Review
- Pyridostigmine improves cardiac function and rhythmicity through RyR2 stabilization and inhibition of STIM1-mediated calcium entry in heart failure.Journal of cellular and molecular medicine · 2021Article
- The NaFrontiers in pharmacology · 2021Article
- Vascular endothelial growth factor promotes atrial arrhythmias by inducing acute intercalated disk remodeling.Scientific reports · 2020Article
- Muscarinic-dependent phosphorylation of the cardiac ryanodine receptor by protein kinase G is mediated by PI3K-AKT-nNOS signaling.The Journal of biological chemistry · 2020Article
- Tetrodotoxin-Sensitive Neuronal-Type NaJournal of the American Heart Association · 2020Article
- Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia.Heart rhythm · 2020Article
- Super-Resolution Imaging Using a Novel High-Fidelity Antibody Reveals Close Association of the Neuronal Sodium Channel NaMicroscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2020Article
- Calcium Handling Defects and Cardiac Arrhythmia Syndromes.Frontiers in pharmacology · 2020Review
- Enhancement of Cardiac Store Operated Calcium Entry (SOCE) within Novel Intercalated Disk Microdomains in Arrhythmic Disease.Scientific reports · 2019Article
- From Bernstein's rheotome to Neher-Sakmann's patch electrode. The action potential.Physiological reports · 2019Review
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 2 countries.
Przemysław B RadwańskiDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA ; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, US ; Division of Pharmacy Practice and Sciences, College of Pharmacy, The Ohio State University, Columbus, OH, US.
Hsiang-Ting HoDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA ; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, US.
Rengasayee VeeraraghavanCenter for Heart and Regenerative Medicine Research, Virginia Tech Carilion Research Institute, Virginia Polytechnic University, Roanoke, VA, USA.
Lucia BrunelloDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA ; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, US.
Bin LiuDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA ; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, US.
Andriy E BelevychDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA ; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, US.
Sathya D UnudurthiDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA ; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, OH, USA.
Michael A MakaraDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA ; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, US.
Silvia G PrioriDivision of Cardiology and Molecular Cardiology, Maugeri Foundation-University of Pavia, Pavia, Italy.
Pompeo VolpeDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Antonis A ArmoundasCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, USA.
Wolfgang H DillmannDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Bjorn C KnollmannDivision of Clinical Pharmacology, Vanderbilt University Medical School, Nashville, TN, USA.
Peter J MohlerDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA ; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, US.
Thomas J HundDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA ; Center for Heart and Regenerative Medicine Research, Virginia Tech Carilion Research Institute, Virginia Polytechnic University, Roanoke, VA, USA.
Sándor GyörkeDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA ; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, US.
The Ohio State University Wexner Medical Center · USThe Ohio State University · USMassachusetts General Hospital · USUniversity of California, San Diego · USUniversity of Padua · ITUniversity of Pavia · ITVanderbilt University · USVirginia Tech · US
Funding
CONTROLLED AND UNCONTROLLABLE CALCIUM RELEASE IN HEARTR01HL063043 · NHLBI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI Sandor Gyorke · 1999 to 2026
$8.6MRyanodine Receptor Channels in Heart FailureR01HL074045 · NHLBI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI GYORKE, SANDOR · 2003 to 2024
$8.2MDefining novel mechanisms for human arrhythmiaR35HL135754 · NHLBI · OHIO STATE UNIVERSITY · PI MOHLER, PETER J. · 2017 to 2023
$6.0MThe Microcirculation in Claudication and Exercise RehabilitationR01HL075649 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FLOYD, THOMAS FREDERICK, MOHLER, EMILE R. · 2003 to 2014
$5.0MRole of spectrin/ankyrin-G complex in myocyte signaling and cardiac excitabilityR01HL083422 · NHLBI · VANDERBILT UNIVERSITY · PI MOHLER, PETER J. · 2006 to 2016
$3.8MRole of ankyrin-B in human arrhythmiaR01HL084583 · NHLBI · UNIVERSITY OF IOWA · PI MOHLER, PETER J. · 2006 to 2015
$3.4MCalsequestrin in Ventricular Arrhythmia and Sudden DeathR01HL088635 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2007 to 2015
$3.2MDefining novel mechanisms for regulation of atrial INa and arrhythmiasR01HL134824 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY, MOHLER, PETER J. · 2017 to 2020
$3.0MToward a Mechanism-Based Approach to Treating Atrial FibrillationR01HL124935 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2015 to 2019
$2.8MCaMKII-dependent regulation of cardiac excitabilityR01HL114893 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY · 2012 to 2016
$1.9MMicrodomain regulation of Ca2+ release in cardiac physiology and diseaseK99HL127299 · NHLBI · OHIO STATE UNIVERSITY · PI RADWANSKI, PRZEMYSLAW · 2015 to 2016
$233kNHLBI NIH HHS K99 HL127299NHLBI NIH HHS R01 HL063043NHLBI NIH HHS R01 HL074045NHLBI NIH HHS R01 HL075649NHLBI NIH HHS R01 HL083422NHLBI NIH HHS R01 HL084583NHLBI NIH HHS R01 HL088635NHLBI NIH HHS R01 HL114893NHLBI NIH HHS R01 HL124935NHLBI NIH HHS R01 HL134824NHLBI NIH HHS R35 HL135754
Abstract
backgroundCardiac arrhythmias are a leading cause of death in the US. Vast majority of these arrhythmias including catecholaminergic polymorphic ventricular tachycardia (CPVT) are associated with increased levels of circulating catecholamines and involve abnormal impulse formation secondary to aberrant Ca METHODS AND
resultsWe performed functional and structural studies to assess Ca
conclusionThese data suggest that the arrhythmogenic alteration in Na
Indexed as
Diastolic Ca2+ releaseNeuronal Na+ channelsVentricular arrhythmiasβ-adrenergic receptor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.