Evidence map›Paper›PMID 27747195›Full record

ArticleFrontiers in cellular and infection microbiology2016

Respiratory Syncytial Virus Aggravates Renal Injury through Cytokines and Direct Renal Injury.

Songhui Zhai, Lijuan Hu, Lin Zhong, Yannan Guo, Liqun Dong, Ruizhen Jia, Zheng Wang

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  3. Article
  4. Review
  5. Observational
  6. Review
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Songhui ZhaiDepartment of Pediatrics, West China Second University Hospital, Sichuan UniversityChengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of EducationSichuan, China.
Lijuan HuDepartment of Immunology, College of Preclinical and Forensic Medicine, Sichuan University Chengdu, China.
Lin ZhongDepartment of Pediatrics, West China Second University Hospital, Sichuan University Chengdu, China.
Yannan GuoDepartment of Pediatrics, West China Second University Hospital, Sichuan University Chengdu, China.
Liqun DongDepartment of Pediatrics, West China Second University Hospital, Sichuan University Chengdu, China.
Ruizhen JiaWest China Institutes of Women and Children's Health, West China Second University Hospital, Sichuan University Chengdu, China.
Zheng WangDepartment of Pediatrics, West China Second University Hospital, Sichuan UniversityChengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of EducationSichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to investigate the relationship between renal injury and reinfection that is caused by respiratory syncytial virus (RSV) and to analyze the mechanism of renal injury. Rats were repeatedly infected with RSV on days 4, 8, 14, and 28, then sacrificed and examined on day 56 after the primary infection. Renal injury was examined by transmission electron microscopy and histopathology. The F protein of RSV was detected in the renal tissue by indirect immunofluorescence. Proteinuria and urinary glycosaminoglycans (GAGs), serum levels of albumin, urea nitrogen, and creatinine, secretion of cytokines, T lymphocyte population and subsets, and dendritic cell (DC) activation state were examined. The results showed that renal injury was more serious in the reinfection group than in the primary infection group. At a higher infection dose, 6 × 10

Indexed as

Acute Kidney InjuryAnimalsCytokinesHistocytochemistryKidneyMaleMicroscopy, Electron, TransmissionMicroscopy, FluorescenceRats, Sprague-DawleyRespiratory Syncytial VirusesRespiratory Syncytial Virus InfectionsCytokinesImmunologic lesionnephrotic syndromereinfectionrenal injuryrespiratory syncytial virus (RSV)

Identifiers

PMID27747195
PMCPMC5043133

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.