Evidence map›Paper›PMID 27747103›Full record

ArticleSchizophrenia research and treatment2016

Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?

Martino Belvederi Murri, Flaminia Fanelli, Uberto Pagotto, Elena Bonora, Federico Triolo, Luigi Chiri, Fabio Allegri, Marco Mezzullo, Marco Menchetti, Valeria Mondelli and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Reduced Gene Dosage of the Psychiatric Risk GeneInternational journal of molecular sciences · 2025
    Article
  2. Steroidomics in Men with Schizophrenia.International journal of molecular sciences · 2024
    Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Martino Belvederi MurriDepartment of Neurosciences, Rehabilitation, Ophthalmology and Genetics, Section of Psychiatry, University of Genova, Genova, Italy; Department of Psychological Medicine, King's College London, London, UK.ORCID 0000-0002-7262-3528
Flaminia FanelliSection of Endocrinology, Department of Medical and Surgical Sciences and Center for Applied Biomedical Research (CRBA), St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.ORCID 0000-0003-2601-2694
Uberto PagottoSection of Endocrinology, Department of Medical and Surgical Sciences and Center for Applied Biomedical Research (CRBA), St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; Bologna Transcultural Psychosomatic Team (BoTPT), Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Elena BonoraBologna Transcultural Psychosomatic Team (BoTPT), Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Section of Medical Genetics, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Federico TrioloBologna Transcultural Psychosomatic Team (BoTPT), Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Luigi ChiriBologna Transcultural Psychosomatic Team (BoTPT), Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Fabio AllegriBologna Transcultural Psychosomatic Team (BoTPT), Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.ORCID 0000-0002-5536-0754
Marco MezzulloSection of Endocrinology, Department of Medical and Surgical Sciences and Center for Applied Biomedical Research (CRBA), St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.ORCID 0000-0001-6748-3041
Marco MenchettiBologna Transcultural Psychosomatic Team (BoTPT), Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Valeria MondelliDepartment of Psychological Medicine, King's College London, London, UK.
Carmine ParianteDepartment of Psychological Medicine, King's College London, London, UK.
Domenico BerardiDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Ilaria TarriconeDepartment of Psychological Medicine, King's College London, London, UK; Bologna Transcultural Psychosomatic Team (BoTPT), Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.ORCID 0000-0002-5786-2520
University of Bologna · ITKing's College London · GBIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · IT

Funding

Medical Research Council G108/603
6 · The paper itself

Abstract

Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (

Identifiers

PMID27747103
PMCPMC5055965
OpenAlexW2522463301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.