ReviewJournal of thoracic disease2016
AME evidence series 001-The Society for Translational Medicine: clinical practice guidelines for diagnosis and early identification of sepsis in the hospital.
Review in Journal of thoracic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Predictive variables for early detection of sepsis in adults admitted to intensive care units: protocol for a systematic review.BMJ open · 2026Article
- Validation of SeptiCyte RAPID to Discriminate Sepsis from Non-Infectious Systemic Inflammation.Journal of clinical medicine · 2024Article
- Impact of sepsis on Eastern Cooperative Oncology Group performance status among fully ambulatory patients: a prospective nationwide multicenter cohort.Journal of thoracic disease · 2023Article
- Classifying sepsis from photoplethysmography.Health information science and systems · 2022Article
- Proadrenomedullin in Sepsis and Septic Shock: A Role in the Emergency Department.Medicina (Kaunas, Lithuania) · 2021Review
- Intra-abdominal infection in acute pancreatitis in eastern China: microbiological features and a prediction model.Annals of translational medicine · 2021Article
- The value of sepsis biomarkers and their kinetics in the prognosis of septic shock due to bacterial infections.Anaesthesiology intensive therapy · 2021Article
- Plasma Microbial Cell-Free DNA Sequencing Technology for the Diagnosis of Sepsis in the ICU.Frontiers in molecular biosciences · 2021Article
- Esmolol inhibits inflammation and apoptosis in the intestinal tissue via the overexpression of NF-κB-p65 in the early stage sepsis rats.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- FatalWorld journal of critical care medicine · 2019Article
- Use of ulinastatin was associated with reduced mortality in critically ill patients with sepsis.Journal of thoracic disease · 2019Article
- Diagnostic and predictive performance of biomarkers in patients with sepsis in an intensive care unit.The Journal of international medical research · 2019Article
- Human recombinant alkaline phosphatase: a promising, yet-to-be-tested agent for the treatment sepsis-induced acute kidney injury.Annals of translational medicine · 2018Article
- Ulinastatin is effective in reducing mortality for critically ill patients with sepsis: a causal mediation analysis.Scientific reports · 2018Article
- Enteral nutrition feeding in Chinese intensive care units: a cross-sectional study involving 116 hospitals.Critical care (London, England) · 2018Article
- Mid-Regional Pro-Adrenomedullin (MR-proADM) as a Biomarker for Sepsis and Septic Shock: Narrative Review.Healthcare (Basel, Switzerland) · 2018Review
- Current aspects in sepsis approach. Turning things around.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018Review
- Laboratory epidemiology of respiratory viruses in a large children's hospital: A STROBE-compliant article.Medicine · 2018Observational
- Time-varying covariates and coefficients in Cox regression models.Annals of translational medicine · 2018Article
- Use of Next Generation Sequencing and Synergy Susceptibility Testing in Diagnosis and Treatment of Carbapenem-ResistantCase reports in infectious diseases · 2018Article
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Authors and funding
26 authors at 14 institutions in 13 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a heterogeneous disease caused by an infection stimulus that triggers several complex local and systemic immuno-inflammatory reactions, which results in multiple organ dysfunction and significant morbidity and mortality. The diagnosis of sepsis is challenging because there is no gold standard for diagnosis. As a result, the clinical diagnosis of sepsis is ever changing to meet the clinical and research requirements. Moreover, although there are many novel biomarkers and screening tools for predicting the risk of sepsis, the diagnostic performance and effectiveness of these measures are less than satisfactory, and there is insufficient evidence to recommend clinical use of these new techniques. As a consequence, diagnostic criteria for sepsis need regular revision to cope with emerging evidence. This review aims to present the most updated information on diagnosis and early recognition of sepsis. Recommendations for clinical use of different diagnostic tools rely on the Grades of Recommendation Assessment, Development and Evaluation (GRADE) framework. Because most of the studies were observational and did not allow a reliable assessment of these tools, a two-step inference approach was employed. Future trials need to confirm or refute a particular index test and should directly explore relevant patient outcome parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.