ArticleJournal of thoracic disease2016
Suppressive oligonucleotides inhibit inflammation in a murine model of mechanical ventilator induced lung injury.
Article in Journal of thoracic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury.Critical care (London, England) · 2023Review
- Ventilator-induced lung-injury in mouse models: Is there a trap?Laboratory animal research · 2021Review
- Dexmedetomidine reduces ventilator-induced lung injury via ERK1/2 pathway activation.Molecular medicine reports · 2020Article
- Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes.Cytokine & growth factor reviews · 2020Article
- Dexmedetomidine reduces ventilator-induced lung injury (VILI) by inhibiting Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signaling pathway.Bosnian journal of basic medical sciences · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMechanical ventilation (MV) is commonly used to improve blood oxygenation in critically ill patients and for general anesthesia. Yet the cyclic mechanical stress induced at even moderate ventilation volume settings [tidal volume (Vt) <10 mL/kg] can injure the lungs and induce an inflammatory response. This work explores the effect of treatment with suppressive oligonucleotides (Sup ODN) in a mouse model of ventilator-induced lung injury (VILI).
methodsBalb/cJ mice were mechanically ventilated for 4 h using clinically relevant Vt and a positive end-expiratory pressure of 3 cmH
resultsMV induced significant pulmonary inflammation characterized by the influx and activation of CD11c
conclusionsTreatment with Sup ODN reduces the lung injury induced by MV in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.