ArticleIranian journal of basic medical sciences2016
Histopathological effects of intramuscular metamizole sodium on rat sciatic nerve.
Article in Iranian journal of basic medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Adverse effects of metamizole on heart, lung, liver, kidney, and stomach in rats.BMC pharmacology & toxicology · 2024Article
- The effect of tropisetron on peripheral diabetic neuropathy: possible protective actions against inflammation and apoptosis.Cell stress & chaperones · 2022Article
- Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination.Northern clinics of Istanbul · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe investigated the histopathological effects of metamizole sodium (MS) on the sciatic nerve. MATERIALS AND
methodsThis study was performed using 48 adult male Wistar albino rats. Ten groups were constituted with 6 rats in each group. MS injection into the sciatic nerve (group 1), MS injection into the muscle [group 3 (50 mg/kg, 0.4 ml) and group 5 (50 mg/kg, 0.8 ml)], MS injection into the muscle cavity in the vicinity of the sciatic nerve [group 2 (50 mg/kg, 0.4 ml) and group 4 (50 mg/kg, 0.8 ml)], normal saline injection into the muscle in the vicinity of the sciatic nerve [group 6A (0.4 ml) and 6B (0.8 ml)], subjected to injury by drilling the entire layer of nerve without injecting any drug, normal saline injection in the sciatic nerve, and control group. Nerve and muscle samples were taken 7 days after administrations. Tissue sections were stained using a hematoxylin and eosin-Luxol® fast blue stain, assessed by a histologist.
resultsThe levels of axonal degeneration of the rats in groups 1, 2, 3, 4, 5, 6A, and 8 were found to be significantly higher compared to the levels of the rats in the control group (
conclusionIt was observed that MS could lead to injury in the sciatic nerve with a toxic effect due to diffusion.
Indexed as
Identifiers
27746863PMC5048117W2515956509What OpenQuestion holds
Registered trials
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