ArticleOriental pharmacy and experimental medicine2016
Comparative study of neuropharmacological, analgesic properties and phenolic profile of Ajwah, Safawy and Sukkari cultivars of date palm (
Article in Oriental pharmacy and experimental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04261595 (Evaluating Dates as a Functional Food for Autism Via Its Prebiotic Effect, Modulation of Anti-Inflammatory and Anti-Oxidative Activity.), which is not on this map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating Dates as a Functional Food for Autism Via Its Prebiotic Effect, Modulation of Anti-Inflammatory and Anti-Oxidative Activity.
Who cites it
11 citing papers in PubMed, 40 citations in OpenAlex.
- HPLC-characterized phenolics from Acer oblongifolium attenuate inflammation, pain, and CNS-related disturbances: docking, edema, nociception, and behavioural studies.Inflammopharmacology · 2026Article
- Valorization of Date Palm (Molecules (Basel, Switzerland) · 2026Review
- From traditional fruit to modern functional food: chemical constituents, bioactive compounds, and therapeutic applications of Sukkari date palm (Frontiers in nutrition · 2025Review
- Bioactivity and Pharmacological Potential of Date Palm (Phoenix dactylifera L.) Against Pandemic COVID-19: a Comprehensive Review.Applied biochemistry and biotechnology · 2022Review
- Aqueous Ajwa dates seeds extract improves memory impairment in type-2 diabetes mellitus rats by reducing blood glucose levels and enhancing brain cholinergic transmission.Saudi journal of biological sciences · 2022Article
- Neuropharmacological Effects ofArchives of Razi Institute · 2022Article
- Antioxidant properties and phenolic profiling by UPLC-QTOF-MS of Ajwah, Safawy and Sukkari cultivars of date palm.Biochemistry and biophysics reports · 2021Article
- Analgesic and Antipyretic Activities of Ethyl Acetate Fraction Tablet ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Physico-Chemical Characterization of Tunisian Canary Palm (Foods (Basel, Switzerland) · 2020Article
- Analgesic Activity, Chemical Profiling and Computational Study onFrontiers in pharmacology · 2018Article
- In Vivo and In Vitro Evaluation of Pharmacological Potentials of Secondary Bioactive Metabolites ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to the rich nutritional value, date palm is also used in various ethnobotanical practices for the treatment of various disease conditions. Present investigation was undertaken to examine the neuropharmacological and antinociceptive effect of the ethanol extract of three date cultivars growing in Saudi Arabia, namely Ajwah, Safawy and Sukkari. Neuropharmacological effect was observed by pentobarbitone induced sleeping time, open field, and hole board test. Antinociceptive activity was tested by acetic acid induced writhing and hot plate test. The date extracts were also subjected to HPLC analysis to detect the presence of common bioactive polyphenols. All the three date extracts extended the pentobarbitone induced sleeping time, reduced locomotor activity in open field test and reduced exploratory behaviour in hole board test in mice. The extracts also reduced acetic acid induced writhing and delayed response time in hot plate test. The activities were stronger for Ajwah than the other two date cultivars. HPLC analysis indicated the presence of
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