ArticleJournal of ginseng research2016
Korean Red Ginseng water extract arrests growth of xenografted lymphoma cells.
Article in Journal of ginseng research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Assessing systemic, developmental, and reproductive toxicity and estrogenicity of Korean red ginseng extract G1899 in juvenile Sprague-Dawley Rats.Journal of ginseng research · 2024Article
- Systemic and molecular analysis dissect the red ginseng induction of apoptosis and autophagy in HCC as mediated with AMPK.Journal of ginseng research · 2023Article
- Prospective Cohort Study of Ginseng Consumption in Association with Cancer Risk: Shanghai Women's Health Study.The Journal of nutrition · 2023Article
- Restorative effects of Rg3-enriched Korean Red Ginseng andJournal of ginseng research · 2022Article
- Screening of Adapalene Microsponges Fabrication Parameters with Insight on the In vitro Biological Effectiveness.Drug design, development and therapy · 2022Article
- Korean Red Ginseng exerts anti-inflammatory and autophagy-promoting activities in aged mice.Journal of ginseng research · 2021Article
- Curcubinoyl flavonoids from wild ginseng adventitious root cultures.Scientific reports · 2021Article
- Developmental and reproductive toxicity assessment in rats with KGC-HJ3, Korean Red Ginseng withJournal of ginseng research · 2019Article
- Effect of Korean Red Ginseng extract on colorectal lung metastasis through inhibiting the epithelial-mesenchymal transition via transforming growth factor-β1/Smad-signaling-mediated Snail/E-cadherin expression.Journal of ginseng research · 2019Article
- AKT-targeted anti-inflammatory activity ofJournal of ginseng research · 2018Article
- Hydroquinone Exhibits In Vitro and In Vivo Anti-Cancer Activity in Cancer Cells and Mice.International journal of molecular sciences · 2018Article
- Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action.Oncotarget · 2018Article
- Src Is a Prime Target Inhibited byEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Tabetri™ (Mediators of inflammation · 2018Article
- Anti-inflammatory effect of torilidis fructus ethanol extract through inhibition of Src.Pharmaceutical biology · 2017Article
- Hydroquinone suppresses IFN-β expression by targeting AKT/IRF3 pathway.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- JS-III-49, a hydroquinone derivative, exerts anti-inflammatory activity by targeting Akt and p38.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- Tabetri™ (Mediators of inflammation · 2017Article
- Anticancer Efficacy ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough numerous studies of the anticancer activities of Korean Red Ginseng (KRG) have been performed, the therapeutic effect of KRG on leukemia has not been fully elucidated. In this study, we investigated the antileukemia activities of KRG and its cellular and molecular mechanisms.
methodsAn established leukemia tumor model induced by xenografted T cell lymphoma (RMA cells) was used to test the therapeutic activity of KRG water extract (KRG-WE). Direct cytotoxic activity of KRG-WE was confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The immunomodulatory activities of KRG-WE were verified by immunohistochemistry, nitric oxide production assay. The inhibitory effect of KRG-WE on cell survival signaling was also examined.
resultsOrally administered KRG-WE reduced the sizes of tumor masses. Levels of apoptosis regulatory enzymes and cleaved forms of caspases-3 and -8 were increased by this extract. In addition, expression of matrix metalloproteinase-9, a metastasis regulatory enzyme, was decreased by KRG-WE treatment. The proportion of CD11c+ cells was remarkably increased in the KRG-treated group compared to the control group. However, KRG-WE did not show significant direct cytotoxicity against RMA cells.
conclusionOur results strongly suggest that the KRG might have antileukemia activity through CD11c+ cell-mediated antitumor immunity.
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