Evidence map›Paper›PMID 27746591›Full record

ArticleMediators of inflammation2016

mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections.

Lijun Fang, Huaijun Tu, Wei Guo, Shixuan Wang, Ting Xue, Fei Yang, Xiaoyan Zhang, Yazhi Yang, Qian Wan, Zhexin Shi and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Lijun FangDepartment of Hematology, The Second Affiliated Hospital of Nanchang University, Key Laboratory of Experimental Hematology in Jiangxi Province, Nanchang, Jiangxi, China; Medical Department of Nanchang University Graduate School, Nanchang, Jiangxi, China.ORCID 0000-0002-2653-9034
Huaijun TuDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Wei GuoState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Tianjin, China.
Shixuan WangState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Tianjin, China.
Ting XueDepartment of Medical Microbiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Fei YangState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Tianjin, China.
Xiaoyan ZhangDepartment of Hematology, The Second Affiliated Hospital of Nanchang University, Key Laboratory of Experimental Hematology in Jiangxi Province, Nanchang, Jiangxi, China; Medical Department of Nanchang University Graduate School, Nanchang, Jiangxi, China.
Yazhi YangDepartment of Hematology, The Second Affiliated Hospital of Nanchang University, Key Laboratory of Experimental Hematology in Jiangxi Province, Nanchang, Jiangxi, China; Medical Department of Nanchang University Graduate School, Nanchang, Jiangxi, China.
Qian WanDepartment of Hematology, The Second Affiliated Hospital of Nanchang University, Key Laboratory of Experimental Hematology in Jiangxi Province, Nanchang, Jiangxi, China; Medical Department of Nanchang University Graduate School, Nanchang, Jiangxi, China.
Zhexin ShiDepartment of Hematology and Oncology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Xulong ZhanDepartment of Hematology, The Second Affiliated Hospital of Nanchang University, Key Laboratory of Experimental Hematology in Jiangxi Province, Nanchang, Jiangxi, China; Medical Department of Nanchang University Graduate School, Nanchang, Jiangxi, China.
Jian LiDepartment of Hematology, The Second Affiliated Hospital of Nanchang University, Key Laboratory of Experimental Hematology in Jiangxi Province, Nanchang, Jiangxi, China.ORCID 0000-0003-2396-5342
Nanchang University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine · CNHuazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The TSC1/2 heterodimer, a key upstream regulator of the mTOR, can inhibit the activation of mTOR, which plays a critical role in immune responses after bacterial infections. Monocytes are an innate immune cell type that have been shown to be involved in bacteremia. However, how the mTOR pathway is involved in the regulation of monocytes is largely unknown. In our study, TSC1 KO mice and WT mice were infected with

Indexed as

AnimalsBacterial InfectionsEscherichia coliFemaleInterleukin-1Interleukin-10Interleukin-6MaleMechanistic Target of Rapamycin Complex 1MiceMice, KnockoutMonocytesMultiprotein ComplexesT-Lymphocytes, RegulatoryTOR Serine-Threonine KinasesTransforming Growth Factor betaInterleukin-1Interleukin-10Interleukin-6Mechanistic Target of Rapamycin Complex 1Multiprotein ComplexesTOR Serine-Threonine KinasesTransforming Growth Factor betaTumor Necrosis Factor-alpha

Identifiers

PMID27746591
PMCPMC5056273
OpenAlexW2525741275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.