Evidence map›Paper›PMID 27746499›Full record

ArticleIndian journal of orthopaedics2016

Human autologous mesenchymal stem cells with extracorporeal shock wave therapy for nonunion of long bones.

Lei Zhai, Xin-Long Ma, Chuan Jiang, Bo Zhang, Shui-Tao Liu, Geng-Yan Xing

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Article in Indian journal of orthopaedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Addition of shock wave therapy to nail dynamization increases the chance of long-bone non-union healing.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2022
    Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lei ZhaiDepartment of Orthopaedic Surgery, The General Hospital of Tianjin Medical University, Tianjin 300052, P. R. China.
Xin-Long MaDepartment of Orthopaedic Surgery, Tianjin Hospital, Hexi District, Tianjin 300211, P. R. China.
Chuan JiangDepartment of Orthopaedic Surgery, The General Hospital of Chinese People's Armed Police Force, Haidian District, Beijing 100039, P. R. China.
Bo ZhangDepartment of Immunology, Tianjin Medical University, Heping District, Tianjin 300052, P. R. China.
Shui-Tao LiuDepartment of Orthopaedic Surgery, The Affiliated Hospital of Logistics College of Chinese People's Armed Police Force, Pingjin Hospital, Hedong District, Tianjin 300162, P. R. China.
Geng-Yan XingDepartment of Orthopaedic Surgery, The General Hospital of Chinese People's Armed Police Force, Haidian District, Beijing 100039, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently, the available treatments for long bone nonunion (LBN) are removing of focus of infection, bone marrow transplantation as well as Ilizarov methods etc. Due to a high percentage of failures, the treatments are complex and debated. To develop an effective method for the treatment of LBN, we explored the use of human autologous bone mesenchymal stems cells (hBMSCs) along with extracorporeal shock wave therapy (ESWT). MATERIALS AND

methodsSixty three patients of LBN were subjected to ESWT treatment and were divided into hBMSCs transplantation group (Group A, 32 cases) and simple ESWT treatment group (Group B, 31 cases).

resultsThe patients were evaluated for 12 months after treatment. In Group A, 14 patients were healed and 13 showed an improvement, with fracture healing rate 84.4%. In Group B, eight patients were healed and 13 showed an improvement, with fracture healing rate 67.7%. The healing rates of the two groups exhibited a significant difference (

conclusionAutologous bone mesenchymal stems cell transplantation with ESWT can effectively promote the healing of long bone nonunions.

Indexed as

bone fracturebone marrow cell transplantationBone mesenchymal stems cellsextracorporeal shock wave therapylong bonenonunion of fractureStem cell researchtransplantation

Identifiers

PMID27746499
PMCPMC5017178

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