Evidence map›Paper›PMID 27746422›Full record

ReviewCirculation journal : official journal of the Japanese Circulation Society2016

Defining the Cardiac Fibroblast.

Malina J Ivey, Michelle D Tallquist

Abstract readReview
In one paragraph

Review in Circulation journal : official journal of the Japanese Circulation Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

168 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. CD160Cellular & molecular immunology · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Advances in RNA modification in myocardial fibrosis (Review).International journal of molecular medicine · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Malina J IveyDepartment of Cell and Molecular Biology, Center for Cardiovascular Research, University of Hawaii.
Michelle D Tallquist

Funding

PDGF Receptor Signaling in Mammalian DevelopmentR01HL074257 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI TALLQUIST, MICHELLE D · 2003 to 2014
$3.7M
The role of PDGF Receptor Signaling in Cardiac FibroblastsF31HL126512 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI IVEY, MALINA JAN · 2015 to 2016
$64k
NHLBI NIH HHS F31 HL126512NHLBI NIH HHS R01 HL074257
6 · The paper itself

Abstract

Cardiac fibrosis remains an important health concern, but the study of fibroblast biology has been hindered by a lack of effective means for identifying and tracking fibroblasts. Recent advances in fibroblast-specific lineage tags and reporters have permitted a better understanding of these cells. After injury, multiple cell types have been implicated as the source for extracellular matrix-producing cells, but emerging studies suggest that resident cardiac fibroblasts contribute substantially to the remodeling process. In this review, we discuss recent findings regarding cardiac fibroblast origin and identity. Our understanding of cardiac fibroblast biology and fibrosis is still developing and will expand profoundly in the next few years, with many of the recent findings regarding fibroblast gene expression and behavior laying down the groundwork for interpreting the purpose and utility of these cells before and after injury. (Circ J 2016; 80: 2269-2276).

Indexed as

Gene Expression RegulationAnimalsFibroblastsFibrosisHeart DiseasesHumansMyocardium

Identifiers

PMID27746422
PMCPMC5588900

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.