Evidence map›Paper›PMID 27746382›Full record

ArticleParasitology international2017

Association between Opisthorchis viverrini and Leptospira spp. infection in endemic Northeast Thailand.

Chinh Dang Van, Galayanee Doungchawee, Sutas Suttiprapa, Yuji Arimatsu, Sasithorn Kaewkes, Banchob Sripa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Are PathogenicTropical medicine and infectious disease · 2024
    Article
  3. Liver Flukes: Clonorchis and Opisthorchis.Advances in experimental medicine and biology · 2024
    Review
  4. Article
  5. Article
  6. Factors Associated with Leptospirosis in Domestic Cattle in Salakphra Wildlife Sanctuary, Thailand.International journal of environmental research and public health · 2019
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Chinh Dang VanTropical Disease Research Laboratory, Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; Center for Public Health & Ecosystem Research, Hanoi School of Public Health, 138 GiangVo st., Ba Dinh, Hanoi, Vietnam.
Galayanee DoungchaweeDepartment of Pathobiology, Faculty of Science, Mahidol University, Thailand.
Sutas SuttiprapaTropical Disease Research Laboratory, Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Yuji ArimatsuTropical Disease Research Laboratory, Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Sasithorn KaewkesParasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Banchob SripaTropical Disease Research Laboratory, Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address: banchob@kku.ac.th.
Khon Kaen University · THMahidol University · TH

Funding

Pathogenesis of Opisthorchiasis induced persistent periductal fibrosis and CCAP50AI098639 · NIAID · KHON KAEN UNIVERSITY · PI THINKHAMROP, BANDIT · 2012 to 2016
$1.6M
NIAID NIH HHS P50 AI098639
6 · The paper itself

Abstract

Opisthorchiasis caused by Opisthorchis viverrini is an important foodborne trematodiasis in Thailand, Laos and Cambodia. Interestingly, the opisthorchiasis endemic region overlaps with an area of leptospirosis emergence. Here we report an association between opisthorchiasis and leptospirosis in Thailand. Of 280 sera collected from villagers living around the Lawa wetland complex in Khon Kaen province, 199 (71%) were seropositive for leptospirosis by immunochromatography. Individuals with O. viverrini infection had a significantly higher rate of leptospirosis than those without (P=0.001). Significant higher leptospirosis prevalence was found in males than females (P=0.002). However, females but not males with O. viverrini infection showed a significantly higher seroprevalence of leptospirosis. Twenty-one of 35 environmental samples from the lake (water, mud and fish skin mucus) were positive for Leptospira spp. DNA sequencing, sequence alignment, and phylogenetic analysis of some positive nested PCR products revealed both pathogenic and intermediate pathogenic strains of Leptospira in the samples. Strikingly, O. viverrini metacercariae from the fish were positive for L. interrogans. These results suggest a close association between opisthorchiasis and leptospirosis. Contact with water, mud or eating raw fish harboring liver fluke metacercariae may be risk factors for Leptospira infection.

Indexed as

Endemic DiseasesAdultAnimalsBacterial ProteinsFemaleHumansLeptospiraLeptospirosisMaleMiddle AgedOpisthorchiasisOpisthorchisPhylogenyPrevalenceSequence Analysis, DNASeroepidemiologic StudiesBacterial ProteinsLawa wetlandLeptospira spp.Leptospirosis, metacercariaeOpisthorchis viverriniThailand

Identifiers

PMID27746382
PMCPMC5391316
OpenAlexW2530981716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.