ArticleArchives of disease in childhood1989
High alkaline phosphatase activity and growth in preterm neonates.
Article in Archives of disease in childhood, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 161 citations in OpenAlex.
- Physical activity programmes for promoting bone mineralisation and growth in preterm infants.The Cochrane database of systematic reviews · 2026Pooled it
- Physical activity programs for promoting bone mineralization and growth in preterm infants.The Cochrane database of systematic reviews · 2014Pooled it
- Changes in Biochemical Parameters of the Calcium-Phosphorus Homeostasis in Relation to Nutritional Intake in Very-Low-Birth-Weight Infants.Nutrients · 2016Trial
- Supplemented vs. unsupplemented human milk on bone mineralization in very low birth weight preterm infants: a randomized clinical trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Trial
- Bone mineralisation in premature infants cannot be predicted from serum alkaline phosphatase or serum phosphate.Archives of disease in childhood. Fetal and neonatal edition · 2002Trial
- Increased bone mineral content of preterm infants fed with a nutrient enriched formula after discharge from hospital.Archives of disease in childhood · 1993Trial
- Randomised trial of nutrition for preterm infants after discharge.Archives of disease in childhood · 1992Trial
- Early diet of preterm infants and development of allergic or atopic disease: randomised prospective study.BMJ (Clinical research ed.) · 1990Trial
- Metabolic bone disease of prematurity screening and individualized enteral mineral supplementation in high-risk neonates: a quality improvement initiative.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Role of fibroblast growth factor-23 as an early marker of metabolic bone disease of prematurity.BMC pediatrics · 2024Observational
- Relationship of caffeine regimen with osteopenia of prematurity in preterm neonates: a cohort retrospective study.BMC pediatrics · 2022Article
- Determination of serum alkaline phosphatase reference in healthy children aged 1-18 years.Caspian journal of internal medicine · 2022Article
- Association of Protein and Vitamin D Intake With Biochemical Markers in Premature Osteopenic Infants: A Case-Control Study.Frontiers in pediatrics · 2020Article
- rAAVrh74.MCK.Molecular therapy. Methods & clinical development · 2019Article
- Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia.The Journal of pediatrics · 2017Article
- Serial serum alkaline phosphatase as an early biomarker for osteopenia of prematurity.Medicine · 2016Observational
- Metabolic bone disease in the preterm infant: Current state and future directions.World journal of methodology · 2015Article
- Prevention of postnatal growth restriction by the implementation of an evidence-based premature infant feeding bundle.Journal of perinatology : official journal of the California Perinatal Association · 2015Article
- Direct and Functional Biomarkers of Vitamin B6 Status.Annual review of nutrition · 2015Review
- Is additional oral phosphate supplementation for preterm infants necessary: an assessment of clinical audit.European journal of pediatrics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a study on 857 infants born preterm, high peak plasma alkaline phosphatase activity was independently related to slower growth rate in the neonatal period, and to a highly significant reduction in attained length at 9 months and 18 months post term. At 18 months the deficit in body length associated with peak neonatal plasma alkaline phosphase activity of 1200 IU/l or more was 1.6 cm (95% confidence interval 0.9 to 2.3 cm) after adjusting for confounding factors. The strength and magnitude of this association between high plasma alkaline phosphase activity and body length was greater than that for any other factor identified, including the infant's sex and the presence of fetal growth retardation. Data are presented that support the view that the high plasma alkaline phosphatase activity reflected early bone mineral substrate deficiency resulting in metabolic bone disease. We speculate that even silent early bone disease may interfere with the control of subsequent linear growth and emphasise the potential importance of providing preterm infants, especially those fed human milk, with adequate substrate for bone mineralisation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.