ArticleBehavioural brain research2017
Analysis of inflammation-induced depression of home cage wheel running in rats reveals the difference between opioid antinociception and restoration of function.
Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- A mouse model to study persistent fatigue.Research square · 2026Article
- Polynitrogen-containing compounds as multi-target sEH/FAAH inhibitors: Structure-activity relationship and pharmacological studies.Bioorganic & medicinal chemistry · 2026Article
- Effect of analgesic treatments on voluntary activity, mechanical sensitivity and muscle regeneration after cardiotoxin injection in mice.Scientific reports · 2025Article
- Interactions of pain and opioids on conditioned place preference in rodents.Psychopharmacology · 2025Review
- Chronic inflammatory pain reduces fentanyl intake during early acquisition of fentanyl self-administration, but does not change motivation to take fentanyl in male and female rats.Pharmacology, biochemistry, and behavior · 2024Article
- Low-Dose Δ9-THC Produces Antinociception in Female, But Not Male Rats.Cannabis and cannabinoid research · 2023Article
- Structure-activity relationship studies of benzothiazole-phenyl analogs as multi-target ligands to alleviate pain without affecting normal behavior.Prostaglandins & other lipid mediators · 2023Article
- Adolescent THC exposure: effects on pain-related, exploratory, and consummatory behaviors in adult male vs. female rats.Psychopharmacology · 2022Article
- Acute pain-related depression of operant responding maintained by social interaction or food in male and female rats.Psychopharmacology · 2022Article
- Morphine restores and naloxone-precipitated withdrawal depresses wheel running in rats with hindpaw inflammation.Pharmacology, biochemistry, and behavior · 2021Article
- Effects of Ketoprofen and Morphine on Pain-Related Depression of Nestlet Shredding in Male and Female Mice.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Considering sex as a biological variable will require a global shift in science culture.Nature neuroscience · 2021Review
- Use of home cage wheel running to assess the behavioural effects of administering a mu/delta opioid receptor heterodimer antagonist for spontaneous morphine withdrawal in the rat.Behavioural brain research · 2021Article
- Impairment in locomotor activity as an objective measure of pain and analgesia in a rat model of osteoarthritis.Experimental and therapeutic medicine · 2020Article
- Pros and Cons of Clinically Relevant Methods to Assess Pain in Rodents.Neuroscience and biobehavioral reviews · 2019Review
- Core Outcome Measures in Preclinical Assessment of Candidate Analgesics.Pharmacological reviews · 2019Review
- Medication overuse headache following repeated morphine, but not [INCREMENT]9-tetrahydrocannabinol administration in the female rat.Behavioural pharmacology · 2018Article
- Anti-migraine effect of ∆European journal of pharmacology · 2018Article
- Depression of home cage wheel running: a reliable and clinically relevant method to assess migraine pain in rats.The journal of headache and pain · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Opioids are effective at inhibiting responses to noxious stimuli in rodents, but have limited efficacy and many side effects in chronic pain patients. One reason for this disconnect is that nociception is typically assessed using withdrawal from noxious stimuli in animals, whereas chronic pain patients suffer from abnormal pain that disrupts normal activity. We hypothesized that assessment of home cage wheel running in rats would provide a much more clinically relevant method to assess opioid efficacy to restore normal behavior. Intraplantar injection of Complete Freund's Adjuvant (CFA) into the right hindpaw depressed wheel running and caused mechanical allodynia measured with the von Frey test in both male and female rats. Administration of an ED
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.