ArticleDevelopmental cell2016
Vamana Couples Fat Signaling to the Hippo Pathway.
Article in Developmental cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Human iPSC-derived heart valve-like assembloids model valve development and disease pathology.Cell stem cell · 2026Article
- Regulation of Hippo signaling by Atrophin in the developing Drosophila wing.Development (Cambridge, England) · 2026Article
- Interactions between the myosin Dachs, the adaptor Dlish, and the palmitoyltransferase Approximated mediate Fat-Dachsous signaling.bioRxiv : the preprint server for biology · 2026Article
- Fat and Dachsous Signaling-Controlling Growth Requires Both Competition and Cooperation: Competitive Interactions at the Cell Cortex Restrict the Ability of an Unusual Protein Complex to Promote Tissue Growth.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- The components and regulation of the Hippo pathway and its relationships with the progression and treatment of Non-small cell lung cancer (NSCLC).Cancer cell international · 2025Review
- Regulation of Hippo signaling and planar cell polarity via distinct regions of the Fat intracellular domain.Development (Cambridge, England) · 2025Article
- The deubiquitylating enzyme Fat facets promotes Fat signalling and restricts tissue growth.Nature communications · 2025Article
- Dachsous and Fat coordinately repress the Dachs-Dlish-Approximated complex to control growth.The Journal of cell biology · 2024Article
- Contributions of the Dachsous intracellular domain to Dachsous-Fat signaling.Development (Cambridge, England) · 2024Article
- The Interaction of Mechanics and the Hippo Pathway inCancers · 2023Article
- Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway.The Journal of cell biology · 2023Article
- The wing imaginal disc.Genetics · 2022Article
- Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins.Frontiers in cell and developmental biology · 2022Review
- Searching beyond the streetlight: Neonicotinoid exposure alters the neurogenomic state of worker honey bees.Ecology and evolution · 2021Article
- Article
- Oriented Cell Divisions Are Not Required for Drosophila Wing Shape.Current biology : CB · 2019Article
- Fat-regulated adaptor protein Dlish binds the growth suppressor Expanded and controls its stability and ubiquitination.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Early girl is a novel component of the Fat signaling pathway.PLoS genetics · 2019Article
- Localization of Hippo Signaling Components in Drosophila by Fluorescence and Immunofluorescence.Methods in molecular biology (Clifton, N.J.) · 2019Article
- The Hippo Signaling Network and Its Biological Functions.Annual review of genetics · 2018Review
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2 authors.
Funding
Abstract
The protocadherins Dachsous and Fat initiate a signaling pathway that controls growth and planar cell polarity by regulating the membrane localization of the atypical myosin Dachs. How Dachs is regulated by Fat signaling has remained unclear. Here we identify the vamana gene as playing a crucial role in regulating membrane localization of Dachs and in linking Fat and Dachsous to Dachs regulation. Vamana, an SH3-domain-containing protein, physically associates with and co-localizes with Dachs and promotes its membrane localization. Vamana also associates with the Dachsous intracellular domain and with a region of the Fat intracellular domain that is essential for controlling Hippo signaling and levels of Dachs. Epistasis experiments, structure-function analysis, and physical interaction experiments argue that Fat negatively regulates Dachs in a Vamana-dependent process. Our findings establish Vamana as a crucial component of the Dachsous-Fat pathway that transmits Fat signaling by regulating Dachs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.