ArticleThe Journal of pediatrics2017
Regional Brain Water Content and Distribution During Diabetic Ketoacidosis.
Article in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Hypertension during Diabetic Ketoacidosis in Children.The Journal of pediatrics · 2020Trial
- Clinical analysis of 20 cases of brain injury caused by diabetic ketoacidosis in children.BMC pediatrics · 2025Article
- Brain alterations and neurologic disorder progression induced by lymphatic dysfunction in the head and neck region.Acta neuropathologica communications · 2025Article
- Relationships among biochemical measures in children with diabetic ketoacidosis.Journal of pediatric endocrinology & metabolism : JPEM · 2023Article
- Protective effect of phillyrin against cerebral ischemia/reperfusion injury in rats and oxidative stress-induced cell apoptosis and autophagy in neurons.Bioengineered · 2022Article
- Brain injury in children with diabetic ketoacidosis: Review of the literature and a proposed pathophysiologic pathway for the development of cerebral edema.Pediatric diabetes · 2021Review
- Acute and chronic neuroinflammation is triggered by diabetic ketoacidosis in a rat model.BMJ open diabetes research & care · 2020Article
- Central Pontine Myelinolysis in Pediatric Diabetic Ketoacidosis.Case reports in critical care · 2018Article
- Imaging for Cerebral Edema in Diabetic Ketoacidosis: Time to Zap the CT?Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo characterize regional differences in brain water distribution and content during diabetic ketoacidosis (DKA) in children and determine whether these differences correlate with regional vascular supply. STUDY
designWe compared changes in brain water distribution and water content in different brain regions during DKA by analyzing magnetic resonance diffusion weighted imaging data collected during DKA and after recovery in 45 children (<18 years of age). We measured the apparent diffusion coefficient (ADC) of water in the frontal and occipital cortex, basal ganglia, thalamus, hippocampus, and medulla. Brain water content was also measured in a subset of patients.
resultsADC values were elevated (suggesting vasogenic cerebral edema) in the frontal cortex, basal ganglia, thalamus, and hippocampus during DKA. In contrast, ADC values in the medulla and the occipital cortex were not increased during DKA, and ADC changes in the medulla tended to be negatively correlated with other regions. Regions supplied by the anterior/middle cerebral artery circulation had greater elevations in both ADC and brain water content during DKA compared with regions supplied by the posterior cerebral artery circulation.
conclusionsADC changes during DKA in the brainstem contrast with those of other brain regions, and changes in both ADC and brain water content during DKA vary according to regional vascular supply. These data suggest that brainstem blood flow might possibly be reduced during DKA concurrent with hyperemia in other brain regions.
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