ArticleThe Journal of pediatrics2017
Blood Level of Inter-Alpha Inhibitor Proteins Distinguishes Necrotizing Enterocolitis From Spontaneous Intestinal Perforation.
Article in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Role of Nutrition in Prevention of Neonatal Spontaneous Intestinal Perforation and Its Complications: A Systematic Review.Nutrients · 2020Pooled it
- Rapid Detection of Inter-alpha Inhibitor Proteins in Neonatal Sepsis and Necrotizing Enterocolitis.medRxiv : the preprint server for health sciences · 2026Article
- Necrotising enterocolitis biomarkers: a systematic review.Frontiers in pediatrics · 2025Review
- Blood Glucose, Lactate and Platelet Count in Infants with Spontaneous Intestinal Perforation versus Necrotizing Enterocolitis-A Pilot Study.Children (Basel, Switzerland) · 2023Article
- Inter-alpha-trypsin inhibitor heavy chain 4: A serologic marker relating to disease risk, activity, and treatment outcomes of rheumatoid arthritis.Journal of clinical laboratory analysis · 2022Article
- Emerging prediction methods for early diagnosis of necrotizing enterocolitis.Frontiers in medicine · 2022Review
- Exogenous inter-α inhibitor proteins prevent cell death and improve ischemic stroke outcomes in mice.The Journal of clinical investigation · 2021Article
- New directions in necrotizing enterocolitis with early-stage investigators.Pediatric research · 2020Review
- Ontogeny of inter-alpha inhibitor protein (IAIP) expression in human brain.Journal of neuroscience research · 2020Article
- Early Protein Markers of Necrotizing Enterocolitis in Plasma of Preterm Pigs Exposed to Antibiotics.Frontiers in immunology · 2020Article
- Successful conservative treatment of intestinal perforation in VLBW and ELBW neonates: a single centre case series and review of the literature.BMC pediatrics · 2019Review
- Recent Potential Noninvasive Biomarkers in Necrotizing Enterocolitis.Gastroenterology research and practice · 2019Review
- Vitamin D and associated perinatal-neonatal outcomes among extremely low-birth-weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2018Observational
- The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?The Journal of pediatrics · 2017Review
- A comparative study of serum and fecal calprotectin levels in necrotizing enterocolitis.Jornal de pediatriaObservational
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo examine circulating levels of inter-alpha inhibitor protein (IaIp) in infants with necrotizing enterocolitis (NEC), spontaneous intestinal perforation (SIP), and matched controls to assess the diagnostic accuracy of IaIp to differentiate NEC from SIP and to compare receiver operating characteristics of IaIp for NEC with C-reactive protein (CRP). STUDY
designA prospective, nested case-control study of infants with feeding intolerance was carried out. Blood and clinical data were collected from 27 infants diagnosed with NEC or SIP and from 26 matched controls admitted to our unit. Infants with modified Bell criteria stage 2 or greater were included as NEC. Clinical, radiologic, and/or surgical findings were used to identify infants with SIP. Controls were matched for gestational age, postnatal age, sex, and birth weight.
resultsMean ± SD IaIp blood levels were 147 ± 38 mg/L, 276 ± 67 mg/L, and 330 ± 100 mg/L in infants with NEC, SIP, and matched controls, respectively (P < .004 and P < .01). Receiver operating characteristics analysis to establish the predictive value of NEC demonstrated areas under curve of 0.98 and 0.63 for IaIp and CRP, respectively.
conclusionsIaIp levels were significantly decreased in infants with NEC compared with SIP and matched controls. The diagnostic accuracy of IaIp for NEC was superior to that of CRP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.