Evidence map›Paper›PMID 27744619›Full record

ArticlePediatric nephrology (Berlin, Germany)2016

Long-term successful liver-kidney transplantation in a child with atypical hemolytic uremic syndrome caused by homozygous factor H deficiency.

Emmanuel Gonzales, Tim Ulinski, Dalila Habes, Georges Deschênes, Véronique Frémeaux-Bacchi, Albert Bensman

Abstract readCase Reports
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Emmanuel GonzalesPediatric Hepatology, AP-HP Hôpital Bicêtre, 78 avenue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Tim UlinskiPediatric Nephrology, AP-HP Hôpital Armand-Trousseau, 26 avenue du Dr Arnold-Netter, 75012, Paris, France.
Dalila HabesPediatric Hepatology, AP-HP Hôpital Bicêtre, 78 avenue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Georges DeschênesPediatric Nephrology, AP-HP Hôpital Robert-Debré, 48 Bd Sérurier, 75019, Paris, France.
Véronique Frémeaux-BacchiLaboratory of Immunology, 20 rue Leblanc, 75015, Paris, France.
Albert BensmanPediatric Nephrology, AP-HP Hôpital Robert-Debré, 48 Bd Sérurier, 75019, Paris, France. albert.bensman@orange.fr.ORCID 0000-0001-9083-7469
Assistance Publique – Hôpitaux de Paris · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRational options for the treatment of end-stage renal disease (ESRD) due to atypical hemolytic uremic syndrome (aHUS) in children are still open to discussion. In the case of human complement factor H (CFH) deficiency, the choice is either kidney transplantation in combination with eculizumab, a humanized anti-C5 monoclonal antibody, or a combined liver-kidney transplantation. CASE-DIAGNOSIS/TREATMENT: A child with a homozygous CFH deficiency underwent a successful liver-kidney transplantation. CFH levels normalized within days. After 6 years of follow-up, the graft function (Cockroft clearance 100 ml min RESULTS AND

conclusionsThe results of this long-term follow-up confirm that combined liver-kidney transplantation remains a reasonable option in patients with ESRD due to aHUS when an identified genetic abnormality of the C3 convertase regulator synthesized in the liver has been identified.

Indexed as

Atypical Hemolytic Uremic SyndromeComplement Factor HConsanguinityGlomerulonephritis, MembranoproliferativeHereditary Complement Deficiency DiseasesHumansInfantKidney DiseasesKidney Failure, ChronicKidney TransplantationLiver TransplantationMalePlasma ExchangeTreatment OutcomeCFH protein, humanComplement Factor HAtypical hemolytic uremic syndromeCombined liver–kidney transplantationComplement factor H deficiencyEnd-stage renal disease

Identifiers

PMID27744619
OpenAlexW2531578367

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.