ArticleEuropean journal of nutrition2018
A mixture of milk and vegetable lipids in infant formula changes gut digestion, mucosal immunity and microbiota composition in neonatal piglets.
Article in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 77 citations in OpenAlex.
- Evidence for the influence of the milk fat globule membrane on bifidobacteria metabolism and cell surface properties.JDS communications · 2026Article
- Plant-based proteins for infant formula: findings and recommendations from the ILSI Europe workshop.Frontiers in nutrition · 2025Review
- Impact of Nutritional Strategies to Prevent Post-Weaning Diarrhoea on Performance, Behaviour, and Microbiota in Piglets from Organic Farming.Animals : an open access journal from MDPI · 2024Article
- Microbiota, metabolic profiles and immune biomarkers in infants receiving formula with added bovine milk fat globule membrane: a randomized, controlled trial.Frontiers in nutrition · 2024Article
- Probiotics alleviate constipation and inflammation in late gestating and lactating sows.NPJ biofilms and microbiomes · 2023Article
- Article
- Low-fat dairy consumption improves intestinal immune function more than high-fat dairy in a diet-induced swine model of insulin resistance.European journal of nutrition · 2023Article
- A comprehensive review on infant formula: nutritional and functional constituents, recent trends in processing and its impact on infants' gut microbiota.Frontiers in nutrition · 2023Review
- The Immunological Role of Milk Fat Globule Membrane.Nutrients · 2022Review
- Roles of Milk Fat Globule Membrane on Fat Digestion and Infant Nutrition.Food science of animal resources · 2022Review
- Effect of Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula on Gut Microbiome and Metabolome at 4 Months of Age.Current developments in nutrition · 2021Article
- Article
- Improving Human Health with Milk Fat Globule Membrane, Lactic Acid Bacteria, and Bifidobacteria.Microorganisms · 2021Review
- Using Nutritional Strategies to Shape the Gastro-Intestinal Tracts of Suckling and Weaned Piglets.Animals : an open access journal from MDPI · 2021Review
- Human milk-based fortifier is associated with less alteration of milk fat globule size than cow milk-based fortifier.PloS one · 2021Article
- Addition of Dairy Lipids and ProbioticFrontiers in nutrition · 2021Article
- The Relationship Between Breast Milk Components and the Infant Gut Microbiota.Frontiers in nutrition · 2021Review
- Bioactive Compounds in Infant Formula and Their Effects on Infant Nutrition and Health: A Systematic Literature Review.International journal of food science · 2021Review
- New Insights Into Microbiota Modulation-Based Nutritional Interventions for Neurodevelopmental Outcomes in Preterm Infants.Frontiers in microbiology · 2021Review
- Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough composition of infant formula has been significantly improved during the last decade, major differences with the composition and structure of breast milk still remain and might affect nutrient digestion and gut biology. We hypothesized that the incorporation of dairy fat in infant formulas could modify their physiological impacts by making their composition closer to that of human milk. The effect of milk fat and milk fat globule membrane (MFGM) fragments in infant formulas on gut digestion, mucosal immunity and microbiota composition was evaluated.
methodsThree formulas containing either (1) vegetable lipids stabilized only by proteins (V-P), (2) vegetable lipids stabilized by a mixture of proteins and MFGM fragments (V-M) and (3) a mixture of milk and vegetable lipids stabilized by a mixture of proteins and MFGM fragments (M-M) were automatically distributed to 42 newborn piglets until slaughter at postnatal day (PND) 7 or 28, and compared to a fourth group of sow's suckling piglets (SM) used as a breast-fed reference.
resultsAt both PND, casein and β-lactoglobulin digestion was reduced in M-M proximal jejunum and ileum contents compared to V-P and V-M ones leading to more numerous β-Cn peptides in M-M contents. The IFNγ cytokine secretion of ConA-stimulated MLN cells from M-M piglets tended to be higher than in V-P ones at PND 7 and PND 28 and was closer to that of SM piglets. No dietary treatment effect was observed on IL-10 MLN cell secretion. Changes in faecal microbiota in M-M piglets resulted in an increase in Proteobacteria and Bacteroidetes and a decrease in Firmicutes phyla compared to V-P ones. M-M piglets showed higher abundances of Parabacteroides, Escherichia/Shigella and Klebsiella genus.
conclusionsThe incorporation of both milk fat and MFGM fragments in infant formula modifies protein digestion, the dynamic of the immune system maturation and the faecal microbiota composition.
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Registered trials
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